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Non-nutritive sweeteners are thought to be useful replacements for caloric sweeteners in sweet food and beverages, since the reduction in energy and carbohydrate intake may lead to health benefits stemming from weight management and glycemic control. However, the potential effects of non-nutritive sweeteners on glucose metabolism and gut hormones have not been determined definitively. Here, the available evidence of the effects of aspartame and sucralose consumption on glucose metabolism and gut hormones is reviewed. A majority of studies have found that consumption of aspartame or sucralose has no effect on concentrations of blood glucose, insulin, or gut hormones; however, 2 trials have shown that aspartame consumption affects glucose, insulin, and glucagon-like peptide 1 concentrations, while only a few trials have shown that sucralose consumption affects glucose, insulin, and glucagon-like peptide 1 concentrations. One study found higher glucose concentrations after sucralose consumption, while 3 studies found lower concentrations and 33 studies found no change in glucose concentrations. Moreover, only 4 studies reported increased concentrations of glucagon-like peptide 1. Three studies reported decreased insulin sensitivity following sucralose consumption, while 1 trial reported an increase in insulin sensitivity. In summary, the evidence from the clinical trials conducted to date is contradictory because of the different protocols used., (© The Author(s) 2020. Published by Oxford University Press on behalf of the International Life Sciences Institute. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)

This study aimed to determine the effect of pure forms of sucralose and aspartame, in doses reflective of commonconsumption, on glucose metabolism. Healthy participants consumed pure forms of a non-nutritive sweetener (NNS) that weremixed with water and standardized to doses of 14% (0.425 g) of the acceptable daily intake (ADI) for aspartame and 20% (0.136 g)of the ADI for sucralose every day for 2 weeks. Blood samples were collected and analyzed for glucose, insulin, active glucagonlikepeptide-1 (GLP-1), and leptin. Seventeen participants (10 females and 7 males; age, 24 �} 6.8 years; body mass index, 22.9 �}2.5 kg/m2) participated in the study. The total area under the curve values of glucose, insulin, active GLP-1 and leptin were similarfor the aspartame and sucralose treatment groups compared with the baseline values in healthy participants. There was nochange in insulin sensitivity after NNS treatment compared with the baseline values. These findings suggest that daily repeatedconsumption of pure sucralose or aspartame for 2 weeks had no effect on glucose metabolism among normoglycaemic adults.However, these results need to be tested in studies with longer durations. [ABSTRACT FROM AUTHOR]