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Background With the rapid progression of aging in China, the challenge of multimorbidity has become a significant concern for both public health and clinical practice. Nocturnal sleep status, including sleep duration and quality, is crucial for regulating body metabolism and physiological functions in the elderly. However, current research on the relationship between nocturnal sleep status and multimorbidity was limited to specific regions or the middle-aged population. The association between nocturnal sleep status and prevalence of multimorbidity among community-dwelling older adults remains ambiguous. Objective To investigate the association between nocturnal sleep status and prevalence of multimorbidity among community-dwelling older adults. Methods In April 2023, a total of 11 917 community-dwelling older adults from the Chinese Longitudinal Healthy Longevity and Happy Family Study (CLHLS-HF, wave 2018) were selected as the participants. Multivariate Logistic regression was used to explore the association of sleep duration and sleep quality with the prevalence of multimorbidity, represented by odds ratios (OR) and 95% confidence intervals (95%CI). Additionally, restrictive cubic splines (RCS) based on Logistic regression analysis were utilized to analyze the dose-response relationship between sleep duration and prevalence of multimorbidity. Results Of the 11 917 community-dwelling older adults, with an average age of (84.4±11.4) years ranged from 65.0 to 117.0 years, 6 477 were females (54.35%) and 5 440 were males (45.65%). Multivariate Logistic regression results after adjusting for covariates such as gender, age, region, and years of education, indicated that compared to those with 6-8 h of nocturnal sleep duration, older adults with shorter sleep duration (

Background: Osteonecrosis of the femoral head (ONFH) is a refractory disease which frequently occurs in young and middle‐aged people. Recent studies indicated that MMP‐14 played an important role in the development of chondrocytes, metabolism of osteoblasts as well as fate decision of hypertrophic chondrocytes. The aim of this study was to investigate the association between polymorphisms of MMP‐14 and steroid‐induced osteonecrosis of the femoral head in the Chinese population. Methods: We selected 7 SNPs (rs3751488, rs1003349, rs1042703, rs2236302, rs1042704, rs2236303, and rs2236304) on gene MMP‐14. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using the chi‐squared test, genetic model analysis, haplotype analysis, and stratification analysis. Results: We discovered that the genotype "G/G" of rs2236302 was associated with ONFH risk in the MMP‐14 in the codominant model (OR = 8.62, 95% CI = 1.07–69.46, p = 0.038) and recessive model (OR = 8.86, 95% CI = 1.10–71.31, p = 0.013). Conclusions: We have confirmed that the susceptive SNPs (rs2236302) of MMP‐14 from the MMPs/TIMPs system exhibit a significant association with increased risk of steroid‐induced ONFH in the population of northern China. The aim of this study was to investigate the association between polymorphisms of MMP‐14 and steroid‐induced osteonecrosis of the femoral head in the Chinese population. We have confirmed that the susceptive SNPs (rs2236302) of MMP‐14 from the MMPs/TIMPs system exhibit a significant association with increased risk of steroid‐induced ONFH in the population of northern China. [ABSTRACT FROM AUTHOR]