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1. Identification of the major allergenic proteins from silkworm moth (Bombyx mori) involved in respiratory allergic diseases.

Author

Araujo LML, Souza C, Zanchin NIT, and Rosário Filho NA

Subjects
Adult, Allergens adverse effects, Animals, Asthma diagnosis, Cross Reactions, Female, Humans, Immunoglobulin E immunology, Inhalation Exposure adverse effects, Insect Proteins adverse effects, Male, Middle Aged, Mites immunology, Rhinitis, Allergic diagnosis, Skin Tests, Allergens immunology, Asthma immunology, Bombyx immunology, Insect Proteins immunology, Rhinitis, Allergic immunology
Abstract

Introduction and Objectives: Moths are a significant source of indoor and outdoor aeroallergens. High prevalence of IgE-mediated sensitization was demonstrated in a group of patients with allergic respiratory diseases. There are no studies on adult stage of these moth species allergens involved in allergic respiratory reactions - the aim of this study., Material and Methods: 36 participants were included in an experimental study, submitted to skin prick test with Bombyx mori wing extract and six other common allergens, as well as Western blot analysis with incubated nitrocellulose membrane impregnated with silkworm moth extract and human IgE-antibody. The participants were divided into 3 groups: 1) 21 allergic patients whose skin prick test was positive to Bombyx mori wing extract, 2) eight allergic patients whose skin prick test was positive to mite and negative to Bombyx mori extract 3) seven negative non-allergic subjects., Results: Among the 21 participants from group 1, 19 serum samples reacted to Bombyx mori extract by Western blot. All of them reacted to a protein at 80 kDa and five other proteins (66, 50, 45, 37 and 30 kDa) were identified in more than 50% of the individuals tested, considered as major allergenic proteins. Sera from seven out of eight patients sensitized to house dust mite demonstrated IgE-reactivity to Bombyx mori extract by Western blot analysis. Serum samples from healthy participants did not react at all., Conclusion: Six major reactive proteins by immunoblot analysis from moth's wings sensitized patients can be potential allergens. The one at 80 kDa is the major protein, seen in all IgE-reactive patients from group 1 and in none from group 2, yet to be identified. Future studies should be conducted to better characterize these proteins., (Copyright © 2020 SEICAP. Published by Elsevier España, S.L.U. All rights reserved.)

Published
2020
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3. Prevalence of asthma and allergic diseases in adolescents: nine-year follow-up study (2003-2012).

Author

Solé D, Rosário Filho NA, Sarinho ES, Camelo-Nunes IC, Barreto BA, Medeiros ML, Franco JM, Camargos PA, Mallol J, Gurgel R, Andrade DM, Furlan FP, Silva AR, Cardozo C, and Andrade C

Subjects
Adolescent, Air Pollution adverse effects, Brazil epidemiology, Follow-Up Studies, Humans, Prevalence, Students statistics & numerical data, Surveys and Questionnaires, Asthma epidemiology, Conjunctivitis, Allergic epidemiology, Dermatitis, Atopic epidemiology, Rhinitis epidemiology
Abstract

Objective: To determine the prevalence of symptoms of asthma, rhinitis, and atopic eczema in adolescents (AD; 13-14 years) living in seven Brazilian cities, by applying the standardized written questionnaire (WQ) of the International Study of Asthma and Allergies in Childhood (ISAAC), and to evaluate the time trend nine years after the last assessment of ISAAC phase 3 (ISP3)., Methods: The ISAAC-WQ was answered by 20,099 AD from the Northern, Northeastern, Southeastern, and Southern Brazilian regions. Values obtained were compared to those observed in ISP3 using nonparametric (chi-squared or Fisher) tests, and the ratio of annual increment/decrement was established for each of the centers, according to the symptom assessed., Results: Considering the national data and comparing to values of ISP3, there was a decrease in the mean prevalence of active asthma (18.5% vs. 17.5%) and an increase in the frequency of severe asthma (4.5% vs. 4.7%) and physician-diagnosed asthma (14.3% vs. 17.6%). An increase in prevalence of rhinitis, rhinoconjunctivitis, and atopic eczema was also observed., Conclusions: The prevalence of asthma, rhinitis, and atopic eczema in Brazil was variable; higher prevalence values, especially of asthma and eczema, were observed in regions located closer to the Equator., (Copyright © 2014 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda. All rights reserved.)

Published
2015
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4. Respiratory allergy to moth: the importance of sensitization to Bombyx mori in children with asthma and rhinitis.

Author

Araujo LM, Rosário Filho NA, and Riedi CA

Subjects
Adolescent, Animals, Asthma epidemiology, Brazil, Child, Cross-Sectional Studies, Female, Humans, Immunoglobulin E blood, Male, Moths immunology, Rhinitis, Allergic, Rhinitis, Allergic, Perennial epidemiology, Skin Tests methods, Allergens immunology, Asthma immunology, Bombyx immunology, Rhinitis, Allergic, Perennial immunology
Abstract

Objective: this study aimed to prepare a silkworm moth (Bombyx mori) antigenic extract and to perform skin prick tests with this extract in patients with allergic respiratory diseases; to evaluate serum specific immunoglobulin E (IgE) to Bombyx mori using ImmunoCAP® system and to report the frequency of positivity between the two methods and with clinical data., Methods: this was a cross-sectional study with 99 children and adolescents diagnosed with asthma and/or allergic rhinitis, who had skin reactivity to at least one of the six aeroallergens tested. Clinical data were evaluated: skin prick tests with Bombyx mori in-house extract, and total and specific IgE analysis using ImmunoCAP® were performed., Results: the frequency of Bombyx mori specific IgE was found to be 52.5% and 60% using the skin prick test and ImmunoCAP®, respectively. An association between a positive skin test for Bombyx mori and the presence of allergic rhinitis, atopic dermatitis, and urticaria was observed, but the same was not true for asthma or allergic conjunctivitis. There was no relation with the severity of asthma or rhinitis symptoms., Conclusions: a high frequency of sensitization to Bombyx mori was observed in a selected population of patients with respiratory allergic diseases in the city of Curitiba, state of Paraná, Brazil. The extract prepared from the wings of this moth species is effective in demonstrating this sensitivity., (Copyright © 2013 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda. All rights reserved.)

Published
2014
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5. [Nebulized budesonide to treat acute asthma in children].

Author

Milani GK, Rosário Filho NA, Riedi CA, and Figueiredo BC

Subjects
Acute Disease, Albuterol administration & dosage, Analysis of Variance, Bronchodilator Agents administration & dosage, Budesonide administration & dosage, Child, Child, Preschool, Double-Blind Method, Female, Humans, Male, Nebulizers and Vaporizers, Placebo Effect, Prospective Studies, Treatment Outcome, Albuterol therapeutic use, Asthma drug therapy, Bronchodilator Agents therapeutic use, Budesonide therapeutic use
Abstract

Objective: To investigate the efficacy of a single dose of inhaled budesonide as compared to oral prednisone in patients with acute asthma., Methods: Randomized double-blind, double-dummy and placebo-controlled clinical trial. Forty-nine children aged 2 to 7 years with acute asthma were randomized in three groups after receiving nebulized salbutamol (0.15 mg/kg). Group I received placebo both as tablets and nebulization, group II was treated with a single dose of oral prednisone (1 mg/kg) and inhaled placebo, and group III received a single dose of placebo tablet and nebulized budesonide (2 mg). Patients were evaluated in terms of symptom score and transcutaneous hemoglobin saturation. Nebulized salbutamol was repeated in case of increasing symptom score or lower saturation., Results: Progressive clinical improvement was observed in all three groups. However, a significant increase in hemoglobin saturation was observed after 2 hours with prednisone, 4 hours with budesonide, and 24 hours with placebo., Conclusion: A combination of single-dose nebulized budesonide and salbutamol may be as effective as oral prednisone to improve symptom severity, but the latter increases hemoglobin saturation in exacerbation of asthma.

Published
2004

6. Waist-to-Height Ratio are Related to Exercise-Induced Bronchoconstriction in Adolescents.

Author

Tadiotto, Maiara C., Lopes, Wendell A., Consentino, Cássio L. M., Silva, Larissa R., Corrazza, Patricia R. P., Menezes-Junior, Francisco J., Rosário-Filho, Nelson A., Radominski, Rosana B., Mota, Jorge, and Leite, Neiva

Subjects
BRONCHOCONSTRICTION, TEENAGERS, WAIST circumference, INVERSE relationships (Mathematics), EXERCISE tests, BODY composition, OXYGEN consumption
Abstract

The purpose of this study was to analyze the frequency of exercise-induced bronchoconstriction (EIB) in asthmatic and nonasthmatic adolescents, as well as to identify the anthropometric and body composition factors associated with EIB. Subjects consisted of 100 adolescents from both sexes with age between 10 and 17 yrs old. Body mass, height, waist circumference (WC), waist-to-height ratio (WtHR), body fat, and peak oxygen consumption were measured. The forced expiratory volume in the first second (FEV1) was measured at rest, and 5, 10, and 15 min after the exercise challenge test. EIB positive (EIB+) was considered to fall =10% in FEV1. Asthma was diagnosed in 19% of the sample and EIB in 18%. EIB+ showed the highest WtHR (P=0.05) with a significant and inverse correlation with maximal fall of FEV1 (P=0.03) and direct with the area above the curve (P=0.03). We concluded that WHtR was the best anthropometric indicator in the evaluation of EIB since greater abdominal adiposity is a mechanical factor that can cause impairment of lung function after intense exercise in adolescents. [ABSTRACT FROM AUTHOR]

Published
2020

7. Prevalence of asthma and allergic diseases in adolescents: nine-year follow-up study (2003-2012)

Author

Solé, Dirceu, Rosário Filho, Nelson A., Sarinho, Emanuel S., Camelo-Nunes, Inês C., Barreto, Bruno A. Paes, Medeiros, Mércia L., Franco, Jackeline Motta, Camargos, Paulo A., Mallol, Javier, Gurgel, Ricardo, Andrade, Djanira M. de, Furlan, Fernanda P., Silva, Almerinda R., Cardozo, Cristina, and Andrade, Cláudia

Subjects
Adolescent, Rhinoconjunctivitis, Epidemiology, Rinoconjuntivite, Atopic eczema, Epidemiologia, Rinite alérgica, Asthma, Allergic rhinitis, Asma, Adolescente, Eczema atópico
Abstract

OBJECTIVE: To determine the prevalence of symptoms of asthma, rhinitis, and atopic eczema in adolescents (AD; 13-14 years) living in seven Brazilian cities, by applying the standardized written questionnaire (WQ) of the International Study of Asthma and Allergies in Childhood (ISAAC), and to evaluate the time trend nine years after the last assessment of ISAAC phase 3 (ISP3). METHODS: The ISAAC-WQ was answered by 20,099 AD from the Northern, Northeastern, Southeastern, and Southern Brazilian regions. Values obtained were compared to those observed in ISP3 using nonparametric (chi-squared or Fisher) tests, and the ratio of annual increment/decrement was established for each of the centers, according to the symptom assessed. RESULTS: Considering the national data and comparing to values of ISP3, there was a decrease in the mean prevalence of active asthma (18.5% vs. 17.5%) and an increase in the frequency of severe asthma (4.5% vs. 4.7%) and physician-diagnosed asthma (14.3% vs. 17.6%). An increase in prevalence of rhinitis, rhinoconjunctivitis, and atopic eczema was also observed. CONCLUSIONS: The prevalence of asthma, rhinitis, and atopic eczema in Brazil was variable; higher prevalence values, especially of asthma and eczema, were observed in regions located closer to the Equator. OBJETIVO: Determinar a prevalência de sintomas relacionados à asma, à rinite e ao eczema atópico em adolescentes (13-14 anos, AD) residentes em sete cidades brasileiras com o questionário escrito (QE) padronizado do International Study of Asthma and Allergies in Childhood (Isaac) e verificar a tendência temporal passados nove anos da última avaliação do Isaac fase 3 (ISF3). MÉTODOS: O QE Isaac foi respondido por 20.099 AD (13-14 anos) moradores em centros das regiões Norte, Nordeste, Sudeste e Sul. Os índices obtidos foram comparados aos do ISF3 com o teste não paramétrico (qui-quadrado ou Fisher) e foi estabelecida a taxa de incremento/decremento anual para cada um dos centros segundo o sintoma avaliado. RESULTADOS: Em relação ao ISF3, considerando-se os dados nacionais, houve queda da prevalência média de asma ativa (18,5% vs. 17,5%) com elevação da frequência de asma grave (4,5% vs. 4,7%) e de asma diagnosticada por médico (14,3% vs. 17,6%). Aumento da prevalência de rinite e rinoconjuntivite e de eczema flexural também ocorreram. CONCLUSÕES: A prevalência de asma, rinite e eczema atópico no Brasil foi variável. Valores mais altos, sobretudo de asma e eczema, foram observados nos centros localizados mais próximos ao Equador.

Published
2015

8. Association between weight gain and the prevalence and severity of wheezing and asthma in the first year of life

Author

Wandalsen,Gustavo, Borges,Leila, Barroso,Nathália, Navarro,Anna Carolina, Suano,Fabíola, Prestes,Elaine, Chong Neto,Herberto, Rosário Filho,Nelson, Bianca,Ana Carolina Dela, Aranda,Carolina, Medeiros,Décio, Sarinho,Emanuel, Moraes,Lilian, Mallol,Javier, and Solé,Dirceu

Subjects
ganho de peso, infants, wheezing, sibilância, lactentes, weight gain, Asma, Asthma
Abstract

Objetivo: Avaliar a relação entre diferentes padrões de ganho de peso no primeiro ano de vida e a prevalência e gravidade de sibilância e asma nesse período. Métodos: Foram analisadas as respostas do questionário EISL de 9159 pais moradores das cidades de São Paulo, Recife, Cuiabá, Curitiba e Belém. Os dados referidos do peso de nascimento e com um ano de vida foram convertidos em Z-scores(z). Foram considerados como tendo ganho de peso acelerado aqueles com diferença entre os pesos superior a 0,67z e ganho de peso excessivo aqueles com diferença superior a 2,01z. Resultados: Ganho de peso acelerado foi observado em 55,7% dos lactentes e ganho excessivo em 20,8%. Lactentes com ganho de peso acelerado apresentaram prevalência significativamente maior de sibilância recorrente (18,9% vs. 18,2%) e hospitalização por sibilância (8,9% vs. 7,5%). Entre os lactentes com ganho de peso excessivo houve significativamente maior prevalência de hospitalização por sibilância (10,1% vs. 7,8%) e diagnóstico médico de asma (8,7% vs. 7,3%). A presença de aleitamento materno por pelo menos seis meses foi significativamente menor naqueles com ganho acelerado de peso (45,2% vs. 51,4%). Conclusões: A maioria dos lactentes avaliados no presente estudo apresentou ganho de peso superior ao esperado durante o primeiro ano de vida. O ganho de peso acelerado e excessivo no primeiro ano de vida foram significativamente associados a formas mais graves de sibilância, enquanto que o ganho de peso excessivo foi associado ao diagnóstico médico de asma, independentemente da presença do aleitamento materno. Objective: To evaluate associations between different patterns of weight gain in the first year of life with the prevalence and severity of wheezing and asthma in infancy. Methods: Answers to the EISL questionnaire from 9159 parents living in the cities of São Paulo, Recife, Cuiabá, Curitiba and Belém were analyzed. Data from reported weight at birth and at one year were converted to Z-scores (z). Rapid weight gain was defined by the difference in weight superior to 0.67z and excessive weight gain by the difference superior to 2.01z. Results: Rapid weight gain was found in 55.7% infants and excessive weight gain in 20.8%. Infants with rapid weight gain showed a significantly higher prevalence of recurrent wheezing (18.9% vs. 18.2%) and hospitalization for wheezing (8.9% vs. 7.5%). Infants with excessive weight gain had a significantly higher prevalence of hospitalization for wheezing (10.1% vs. 7.8%) and medical diagnosis of asthma (8.7% vs. 7.3%). Breastfeeding for at least six months was significantly less frequent among infants with rapid weight gain (45.2% vs. 51.4%). Conclusions: The majority of the evaluated infants showed weight gain above expected in the first year of life. Rapid and excessive weight gain in the first year of life were significantly associated with more severe patterns of wheezing in infancy, while excessive weight gain was associated with the medical diagnosis of asthma, independently from the presence of breastfeeding.

Published
2013

9. Phadiatop® no diagnóstico de alergia respiratória em crianças: Projeto Alergia (PROAL)

Author

Naspitz, Charles K., Solé, Dirceu, Aguiar, Maria Cecília, Chavarria, Maria Letícia, Rosário Filho, Nelson, Zuliani, Antônio, Toledo, Eliana C., Barreto, Bruno A. P., and Souza, Leda S. F.

Subjects
asma, food hypersensitivity, rinithis, Allergy, hipersensibilidade alimentar, rinite, Alergia, IgE, asthma
Abstract

OBJETIVO: Avaliar a positividade do Phadiatop® em crianças acompanhadas em serviços brasileiros de alergologia e compará-la aos resultados de IgE sérica específica a alérgenos inalantes e alimentares. CASUÍSTICA E MÉTODO: Em 457 crianças acompanhadas em serviços de alergia pediátrica e um grupo de crianças controle não-alérgicas (n = 62), distribuídas em cinco faixas etárias, foram determinados em amostra de soro: Phadiatop® e IgE específica (RAST) a alérgenos inalantes e alimentares (UniCAP - Pharmacia®). RESULTADOS: O Phadiatop® foi positivo em 305 crianças atópicas (67,6%) e em 25,8% das controles (p < 0,001). Entre as crianças atópicas, a distribuição de positividade variou de acordo com a faixa etária: 7,9% (24/305) entre as abaixo de 2 anos, 15,4% (47/305) nas de 2 a 3 anos, 22,0% (67/305) nas de 3 a 4 anos, 19,3% (59/305) nas de 4 a 5 anos e 35,4% (108/305) nas de 5 a 12 anos. Não houve concordância entre os alérgenos alimentares e a presença de Phadiatop® positivo. O estudo da relação entre os RAST positivos para alérgenos inalados e o Phadiatop® positivo mostrou melhores índices com os ácaros domiciliares (D. pteronyssinus, D. farinae e Blomia tropicalis). CONCLUSÕES: O Phadiatop®é método útil no diagnóstico de alergia aos ácaros domiciliares. OBJECTIVES: To evaluate the positivity of Phadiatop® in children from several Brazilian pediatric allergology centers and to compare its results with the presence of serum specific IgE to inhalant and food allergens. PATIENTS AND METHOD: Phadiatop® and serum specific IgE levels (RAST) to inhalant and food allergens (UniCAP - Pharmacia®) were measured in 457 children from several pediatric allergy centers and in a non-allergic control group (n = 62), distributed across five age groups. RESULTS: Phadiatop was positive in 305 atopic children (67.6%) and in 25.8% of controls (p < 0.001). Among atopic children the distribution of positive test varied according to age: 7.9% (24/305) among under 2 year-olds, 15.4% (47/305) in 2 to 3 year-olds, 22% (67/305) in 3 to 4 year-olds, 19.3% (59/305) in 4 to 5 year-olds and 35.4% (108/305) in 5 to 12 year-olds. No concordance between food allergens and Phadiatop® was observed. Analysis of the relationship between positive inhaled allergen RASTs and positive Phadiatop® showed best indices with house dust mites (D. pteronyssinus, D. farinae and Blomia tropicalis). CONCLUSIONS: Phadiatop® is a useful tool for diagnosing domestic mite allergy.

Published
2004

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