1. What place will tezepelumab hold in the treatment paradigm in chronic rhinosinusitis?
- Author
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Favier, Valentin, Charriot, Jérémy, Crampette, Louis, Bourdin, Arnaud, and Ahmed, Engi
- Subjects
NASAL polyps ,SINUSITIS ,THYMIC stromal lymphopoietin ,CELL receptors ,ASTHMATICS ,IMMUNOGLOBULIN E - Abstract
Nasal polyps, T2 inflammation, Chronic Rhinosinusitis, Tezepelumab, biologics, asthma, eosinophils Targeting T2 inflammation in CRSwNP, and especially TSLP, may reverse structural changes such as nasal polyps through the "reprogramming" of structural cells and their interaction with the environment. Keywords: Chronic Rhinosinusitis; nasal polyps; T2 inflammation; Tezepelumab; biologics; asthma; eosinophils EN Chronic Rhinosinusitis nasal polyps T2 inflammation Tezepelumab biologics asthma eosinophils 821 825 5 07/31/23 20230801 NES 230801 1. Recent cases in the literature report the combination of biologics in severe asthma, either to reach a better control of asthma in poor controlled severe asthma patients or insufficiently controlled associated comorbidities such as CRSwNP. [Extracted from the article]
- Published
- 2023
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