1. N-Acetyl-l-cysteine ameliorates gestational diabetes mellitus by inhibiting oxidative stress.
- Author
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Xing, Shushan, Guo, Zhizhen, Lang, Jie, Zhou, Miao, Cao, Jianfang, He, Hongyu, Yu, Luyan, and Zhou, Yang
- Subjects
GESTATIONAL diabetes ,OXIDATIVE stress ,ORAL drug administration ,BIRTH size ,INSULIN sensitivity ,DYSLIPIDEMIA ,ATHEROSCLEROSIS - Abstract
Objective: Gestational diabetes mellitus (GDM) affects 7% of pregnant women worldwide. How to effectively treat GDM has always been a concern of people.Research methods: In this study, a diabetes model was established by drug-induced mice. Subsequently, the blood glucose levels and serum insulin changes of the mice after N-acetyl-l-cysteine (NAC) treatment were observed. At the same time, the effect of NAC on reproduction of GDM mice was recorded.Results of the study: Mice fed NAC showed significantly improved glucose tolerance and insulin sensitivity compared to Diabetic/Control. Total serum cholesterol, serum triglycerides, and serum low-density lipoprotein were significantly reduced, and atherosclerosis index was much lower than in control mice. In addition, Diabetic/Control mice had lower litter sizes and higher birth weights. NAC treatment significantly restored litter size and reduced birth weight in Diabetic/Control mice. It was found in WB assay that the NAC-fed group significantly increased nuclear Nrf2 and HO-1 expression levels.Conclusion: NAC can improve blood glucose tolerance in GDM mice; NAC effectively relieves the symptoms of hyperlipidemia caused by GDM; NAC enhances the expression of Nrf2/HO-1 in the liver, thereby restoring redox homeostasis. NAC can reduce gestational diabetes-related disease indicators by oral administration, and has a beneficial effect on the offspring of pregnant mice (reduces its diabetes disease indicators). [ABSTRACT FROM AUTHOR]
- Published
- 2023
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