1. Mechanism of oxidized phospholipid-related inflammatory response in vascular ageing.
- Author
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Wang T, Wang Y, Zhang X, Xu W, Jin K, Pang Y, Wu Y, Luo J, Xu R, Jiao L, and Li W
- Subjects
- Humans, Aged, Inflammation drug therapy, Inflammation metabolism, Oxidation-Reduction, Aging, Phospholipids metabolism, Atherosclerosis drug therapy, Atherosclerosis metabolism
- Abstract
Vascular ageing is an important factor in the morbidity and mortality of the elderly. Atherosclerosis is a characteristic disease of vascular ageing, which is closely related to the enhancement of vascular inflammation. Phospholipid oxidation products are important factors in inducing cellular inflammation. Through interactions with vascular cells and immune cells, they regulate intracellular signaling pathways, activate the expression of various cytokines, and affect cell behavior, such as metabolic level, proliferation, apoptosis, etc. Intervention in lipid metabolism and anti-inflammation are the two key pathways of drugs for the treatment of atherosclerosis. This review aims to sort out the signaling pathway of oxidized phospholipids-induced inflammatory factors in vascular cells and immune cells and the mechanism leading to changes in cell behavior, and summarize the therapeutic targets in the inflammatory signaling pathway for the development of atherosclerosis drugs., Competing Interests: Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Elsevier B.V. All rights reserved.)
- Published
- 2023
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