1. Differential Phagocytosis-Based Photothermal Ablation of Inflammatory Macrophages in Atherosclerotic Disease
- Author
-
Kaichuang Ye, Jinbao Qin, Dan J. L. Brett, Feili Lai, Xinwu Lu, Bo Li, Xin Wang, Xiaoyu Wu, Guanjie He, and Ivan P. Parkin
- Subjects
Male ,Materials science ,Cell Survival ,Infrared Rays ,Phagocytosis ,Cell ,Metal Nanoparticles ,Apoptosis ,Bone Marrow Cells ,Inflammation ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,Mice ,medicine ,Animals ,Humans ,Macrophage ,Tissue Distribution ,General Materials Science ,Photothermal ablation ,Mice, Knockout ,Molybdenum ,Macrophages ,Therapeutic effect ,Endothelial Cells ,Oxides ,Phototherapy ,Photothermal therapy ,Atherosclerosis ,021001 nanoscience & nanotechnology ,0104 chemical sciences ,Endothelial stem cell ,Disease Models, Animal ,Carotid Arteries ,medicine.anatomical_structure ,Semiconductors ,Cancer research ,medicine.symptom ,0210 nano-technology - Abstract
Inflammatory macrophage (Mφ)-mediated atherosclerosis is a leading cause of mortality and morbidity worldwide. Photothermal therapy (PTT) has been demonstrated as an efficient strategy in killing target cells, and its application in the treatment of inflammation in atherosclerosis is developing. However, the choice of nanomaterials, mechanisms, and side effects are seldom considered. In this study, semiconductor nanomaterials, that is, MoO2 nanoclusters, were synthesized and used for the first time in PTT for inflammatory Mφ-mediated atherosclerosis. Based on cell differential phagocytosis, the optimum amount of MoO2 and treatment time were selected to exert the maximum ablation effect on Mφ and minimal damage on endothelial cells without requiring additional target or selective groups. Moreover, MoO2-based PTT shows an excellent therapeutic effect on atherosclerosis by eliminating Mφ in animal models, with no significant side effects observed. This study explores a new method of nanotechnology and pharmaceutical development by using and optimizing cost-effective metal oxide nanostructures in the treatment of atherosclerosis and motivates further research on minimizing the side effects of related materials.
- Published
- 2019