1. Increased Soluble CD137 Levels and CD4+ T-Cell-Associated Expression of CD137 in Acute Atherothrombotic Stroke.
- Author
-
He Y, Ao DH, Li XQ, Zhong SS, A R, Wang YY, Xiang YJ, Xu BL, Yang TT, Gao XG, and Liu GZ
- Subjects
- Aged, Atherosclerosis complications, Atherosclerosis immunology, CD4-Positive T-Lymphocytes immunology, Case-Control Studies, Female, Humans, Male, Middle Aged, Stroke etiology, Stroke immunology, Thrombosis etiology, Thrombosis immunology, Tumor Necrosis Factor Receptor Superfamily, Member 9 immunology, Tumor Necrosis Factor Receptor Superfamily, Member 9 metabolism, Atherosclerosis blood, CD4-Positive T-Lymphocytes metabolism, Stroke blood, Thrombosis blood, Tumor Necrosis Factor Receptor Superfamily, Member 9 blood
- Abstract
As a proinflammatory cytokine, CD137 (4-1BB, TNFRSF9) is present in membrane-bound and soluble forms. Increased expression of CD137 was recently found in T cells in human atherosclerotic plaques. However, the exact role of CD137 in ischemic stroke is not clear. In this study we analyzed the protein levels of soluble CD137 (sCD137) and the expression of CD137 on CD4+ T cells in the peripheral blood of patients with acute atherothrombotic stroke by using the cytometry beads array (CBA) and flow cytometry. Within 24 hours of onset, the stroke patients showed elevated levels of sCD137 (2.7 pg/ml) and CD137 expression on CD4+ T cells (4.9 ± 3.2%) compared with normal controls (1.1 pg/ml, P < 0.01; 1.3 ± 1.0%, P < 0.01). Alterations in CD137 expression may enhance ischemia-induced inflammatory responses via bidirectional signaling and, consequently, aggravate brain injury in early stages of this disorder., (© 2018 The Authors. Clinical and Translational Science published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics.)
- Published
- 2018
- Full Text
- View/download PDF