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We report on an extrinsic surface plasmon-enhancedrefractometer based on cladding mode resonance excitation in a photonic crystal fiber (PCF) equipped with a straight fiber Bragggrating (FBG). First, we show that the lattice pitch and the air hole diameter of the PCF microstructure define the spectral locationof the excited cladding mode resonances. Second, we demonstrate that if the PCF parameters are properly selected, those resonancesare sensitive to increases in steps of 1×10−4 refractive index units(RIU) of the refractive index value close to that of water. To thebest of our knowledge, this is the first time that the sensitivity of PCF cladding mode resonances to refractive index changesin water-based solutions is reported. We achieved experimental values of 40.3 nm/RIU in terms of wavelength sensitivity and −801dB/RIU in terms of amplitude sensitivity. The performance of our sensor is therefore comparable to that of tilted FBGs in step-indexfibers used for water refractometry, which indicates the potential ofour PCF sensor for biosensing. In addition, the sensor fabricationdoes not require any post-processing such as etching or polishing,which allows preserving the integrity of the fiber probe. Finally, thenarrowspectrum within which the PCF operates, allows envisagingmulti-target detection with a single fiber probe by using cascadedwavelength-multiplexed gratings.

Tomographic coherent imaging requires the reconstruction of a series of two-dimensional projections of the object. We show that using the solution for the image of one projection as the starting point for the reconstruction of the next projection offers a reliable and rapid approach to the image reconstruction. The method is demonstrated on simulated and experimental data. This technique also simplifies reconstructions using data with curved incident wavefronts.

Fringe pattern based measurement techniques are the state-of-the-art in full-field optical metrology. They are crucial both in macroscale, e.g., fringe projection profilometry, and microscale, e.g., label-free quantitative phase microscopy. Accurate estimation of the local fringe orientation map can significantly facilitate the measurement process in various ways, e.g., fringe filtering (denoising), fringe pattern boundary padding, fringe skeletoning (contouring/following/tracking), local fringe spatial frequency (fringe period) estimation, and fringe pattern phase demodulation. Considering all of that, the accurate, robust, and preferably automatic estimation of local fringe orientation map is of high importance. In this paper we propose a novel numerical solution for local fringe orientation map estimation based on convolutional neural network and deep learning called DeepOrientation. Numerical simulations and experimental results corroborate the effectiveness of the proposed DeepOrientation comparing it with a representative of the classical approach to orientation estimation called combined plane fitting/gradient method. The example proving the effectiveness of DeepOrientation in fringe pattern analysis, which we present in this paper, is the application of DeepOrientation for guiding the phase demodulation process in Hilbert spiral transform. In particular, living HeLa cells quantitative phase imaging outcomes verify the method as an important asset in label-free microscopy.

The behavior of self-assembly of C60 molecules in solutions of C60/hexane/xylene were studied by the methods of refractometry, ultraviolet–visible spectroscopy and dynamic light scattering (DLS). I...

The design of a refractometric sensing system for liquids analysis with a sensor and the scheme for its intensity interrogation combined on a single photonic integrated circuit (PIC) is proposed. A racetrack microring resonator with a channel for the analyzed liquid formed on the top is used as a sensor, and another microring resonator with a lower Q-factor is utilized to detect the change in the resonant wavelength of the sensor. As a measurement result, the optical power at its drop port is detected in comparison with the sum of the powers at the through and drop ports. Simulations showed the possibility of registering a change in the analyte refractive index with a sensitivity of 110 nm per refractive index unit. The proposed scheme was analyzed with a broadband source, as well as a source based on an optoelectronic oscillator using an optical phase modulator. The second case showed the fundamental possibility of implementing an intensity interrogator on a PIC using an external typical single-mode laser as a source. Meanwhile, additional simulations demonstrated an increased system sensitivity compared to the conventional interrogation scheme with a broadband or tunable light source. The proposed approach provides the opportunity to increase the integration level of a sensing device, significantly reducing its cost, power consumption, and dimensions.

This work describes a 3D-printed optofluidic fiber sensor to measure refractive index in real time, combining a microfluidic system with an optical fiber extrinsic Fabry–Perot interferometer. The microfluidic chip platform was developed for this purpose through 3D printing. The Fabry–Perot cavity was incorporated in the microfluidic chip perpendicularly to the sample flow, which was of approximately 3.7 µL/s. The optofluidic fiber sensor platform coupled with a low-cost optical power meter detector was characterized using different concentrations of glucose solutions. In the linear regression analysis, the optical power shift was correlated with the refractive index and a sensitivity of −86.6 dB/RIU (r2 = 0.996) was obtained. Good results were obtained in terms of stability with a maximum standard deviation of 0.03 dB and a sensor resolution of 5.2 × 10−4 RIU. The feasibility of the optofluidic fiber sensor for dynamic analyses of refractive index with low sample usage was confirmed through real-time measurements.

We put forward a dual-mode photonic crystal nanobeam cavity for simultaneous sensing of the refractive index (RI) and temperature (T) designed with the assistance of artificial neural networks (ANNs). We choose the structure of quadratically tapered elliptical holes with a slot to improve the sensitivities of the two modes. To reduce the time consumption of the design, the ANNs are trained to predict the band structure and to inverse design the geometric structure. For the forward prediction and the inverse design neural networks, low mean square errors of 5.1 × 1 0 − 4 and 1.4 × 1 0 − 2 are achieved, respectively. Through a specific design of band properties by the well-trained neural networks, a dual-mode nanobeam sensor with high quality factors of 9.34 × 1 0 4 and 1.55 × 1 0 5 and a small footprint of 23.8 × 0.7 µ m 2 are designed. The RI and T sensitivities of the air mode are 405 nm/RIU and 40 pm/K, respectively, whereas those of the dielectric mode are 531 nm/RIU and 27 pm/K, respectively. The present work shows significance in further research on the design and applications for dual-mode cavities.

A fiber surface plasmon resonance (SPR) sensor is widely used in high-sensitivity refractive index measurement, but there is less research on curvature measurement. In this paper, a single-mode fiber curvature sensor based on SPR is designed and fabricated. By employing bending, the transmitted light in the fiber core leaks into the cladding. A 50 nm gold film is coated outside the cladding, and the evanescent field of the cladding after bending contacts the gold film to cause SPR. When the curvature changes, the coupled cladding mode and intensity are different; that is, the SPR incident angle and evanescent field intensity are different, so as to realize the dual parameters of SPR resonance wavelength and depth of the resonance valley changing with curvature. By experiments, the influence of different cutoff wavelengths of single-mode fiber on the performance of the sensor is studied. The testing results indicate that with the decrease in cutoff wavelength of the single-mode fiber, the valley depth sensitivity of the sensor increases, and the half height width (FWHM) decreases. When the cutoff wavelength of the single-mode fiber is 630 nm, the valley depth sensitivity of the sensor is 0.0088 a . u / m − 1 , the wavelength sensitivity is 0.26 n m / m − 1 , and the average FWHM is only 21 nm. The proposed single-mode fiber curvature sensor based on SPR has a narrow FWHM and an opening threshold. It can also realize no opening threshold by introducing a coreless fiber, which provides a new solution, to the best of our knowledge, for the diversified detection of fiber SPR sensors.

Salinity is an important environmental factor regulating the aquatic system structure of lakes and other water bodies. Changes in salinity, which can be caused by human activities, can adversely impact the life of water organisms. The refractive index, which can be directly related to water salinity, also controls the polarimetric properties of light reflected from the water surface. In this study, polarimetric measurements of smooth water surfaces with different salinity content were performed at different viewing zenith angles in the wavelength range of 450–1000 nm in the specular reflection directions. The results show that the light reflected from the water surface (defined as reflectance factor) in one measurement direction can be replaced by the reflectance factor derived from polarimetric measurements, and if the polarizer absorptance is considered, the average relative difference is less than 3%. The degree of linear polarization (DOLP) was used to retrieve the refractive indices of water with different salinities based on the Fresnel reflection coefficient. The inverted refractive indices not only have high accuracy (uncertainty from 0.9% to 1.8%) but also have a very strong relationship with the water salinity content. Our study shows the possibility of estimating the variation in water salinity using multi-angular polarimetric measurements.

The fiber surface plasmon resonance (SPR) sensor is widely used in high-sensitivity refractive index detection, and there are few reports on SPR sensors used for strain measurement. In this paper, we propose and demonstrate an S-type fiber strain sensor based on SPR. The simulation and testing results indicate that the smaller the vertical axis offset of S-type fiber is, the larger the incidence angle of SPR is, and the closer the working band of SPR is to the shorter wavelength direction. By electrofusion, we fabricated an S-type structure on the single-mode fiber, and by the S-type structure, the high-order cladding mode was excited. A 50 nm gold film was coated on the surface of the fiber cladding behind the S-type structure. The evanescent field of the cladding mode contacted the gold film to produce SPR, and the strain can change the vertical axis offset of the S-type fiber and further change the incidence angle of SPR; hence an S-type fiber strain sensor based on SPR was realized. When the refractive index of the ambient medium is 1.345 RIU, the vertical axis offset and length of the S-shaped structure are 87 and 501 µm, respectively, the resonance wavelength of the fiber SPR strain sensor changes from 648.06 to 631.77 nm with a strain detection range of 0 − 1200 µ ε , and its sensitivity is − 14.38 p m / µ ε . The proposed sensor provides a new solution for the strain measurement of the fiber SPR sensor, which is expected to be used in the fields of engineering, health monitoring, and early warning.

We propose and demonstrate a highly sensitive refractive index (RI) and temperature sensor based on an asymmetric fiber coupler (AFC). The AFC was fabricated by weak fusion of a pre-stretched single-mode fiber and a few-mode fiber. An ultra-sensitivity RI can be achieved near the dispersion turning point (DTP). The proposed RI sensor achieves a high RI sensitivity of − 10 , 662.4 n m / R I U within the RI range of 1.31–1.35. By packaging the AFC into polydimethylsiloxane (PDMS), the temperature sensitivity reaches 11.44 nm/°C. The proposed AFC with high RI and temperature sensitivity can be potentially used in the field of chemical monitoring, biochemical detection, and clinical diagnosis.

A metal–insulator–metal (MIM) waveguide system consisting of a MIM waveguide, a ring cavity, and a semi-ring cavity is proposed. Using the finite element method, the transmission characteristics of the MIM waveguide system are discussed under the different geometry parameters. By detecting the resonance wavelength and varying the refractive index, the sensing performance of the MIM waveguide system is analyzed. The proposed structure can be used as a refractive index sensor with the maximum sensitivity of 2412 nm/RIU. Due to isolating the ring cavity and semi-ring cavity, the independent tuning of double resonances can be realized by changing the refractive index of the insulator in the ring cavity or the semi-ring cavity. Benefiting from two independent refractive index sensing modes, the structure with two isolated resonators can realize the simultaneous measurement of glucose solution concentration and blood plasma concentration. The sensitivity of glucose solution sensing in the ring cavity is 0.13133 nm/(g/L). Meanwhile, the blood plasma concentration detection in the semi-ring cavity is realized with the sensitivity of 0.358 nm/(g/L). The system with two isolated cavities has the potential to be used as an efficient nano sensor, which can achieve simultaneous measurement of two parameters.

Here, we experimentally demonstrate a wedged fiber optic surface plasmon resonance (SPR) sensor enabling high-sensitivity temperature detection. The sensing probe has a geometry with two asymmetrical bevels, with one inclined surface coated with an optically thin film supporting propagating plasmons and the other coated with a reflecting metal film. The angle of incident light can be readily tuned through modifying the beveled angles of the fiber tip, which has a remarkable impact on the refractive index sensitivity of SPR sensors. As a result, we measure a high refractive index sensitivity as large as 8161 nm/RIU in a wide refractive index range of 1.333–1.404 for the optimized sensor. Furthermore, we carry out a temperature-sensitivity measurement by packaging the SPR probe into a capillary filled with n-butanol. This showed a temperature sensitivity reaching up to −3.35 nm/°C in a wide temperature range of 20 °C–100 °C. These experimental results are well in agreement with those obtained from simulations, thus suggesting that our work may be of significance in designing reflective fiber optic SPR sensing probes with modified geometries.

Gold-coated tilted fiber Bragg gratings (TFBG) are refined plasmonic biosensors, highly sensitive to surrounding refractive index (RI) changes. Their interrogation usually relies on insertion loss measurements for single input polarized light, limiting the set of exploitable features. To overcome this limitation, we trigger the Jones formalism to retrieve the polarization enabling optimized plasmonic excitation for both phase and amplitude measurements. We present an experimental phase shift with a sensitivity as high as 45835°/RIU and further assess this approach to HER2 proteins sensing at 1µg/ml. We compare this angular modality with the one relying on the insertion loss using a quality factor that takes the shift as well as the dispersion into account. This strengthens its relevance in terms of precision for ultra-small RI variations.

A high-sensitivity surface plasmon resonance (SPR) sensor based on the coupling of Au grating and Au film is investigated through simulations and experiments. The SPR sensor is designed by using a hybrid method composed of genetic algorithm (GA) and rigorous coupled wave analysis (RCWA). The numerical results indicate the sensor has an angular sensitivity of 397.3°/RIU (refractive index unit), which is approximately 2.81 times higher than the conventional Au-based sensor and it is verified by experiments. Theoretical analysis, by finite-difference time-domain (FDTD) method, demonstrates the co-coupling between surface plasmon polaritons (SPPs) propagating on the surface of Au film and localized surface plasmons (LSPs) in the Au grating nanostructure, improving the sensitivity of the SPR sensor. According to the optimized structural parameters, the proposed sensor is fabricated using e-beam lithography and magnetron sputtering. In addition, the proposed sensor is very sensitive to the detection of small molecules. The limit of detection (LOD) for okadaic acid (OA) is 0.72 ng/mL based on an indirect competitive inhibition method, which is approximately 38 times lower than the conventional Au sensor. Such a high-sensitivity SPR biosensor has potential in the applications of immunoassays and clinical diagnosis.

We propose an optical-fibre metal-insulator-metal (MIM) plasmonic sensor based on the Fano resonances of surface plasmon polaritons (SPPs). Its structure consists of a coupling fibre that connects C-shaped and rectangular cavities and a main fibre that contains a semi-circular resonator. When incident light passes through the main fibre, it excites SPPs along the interface between the metal and medium. The SPPs at the resonator induce Fano resonances, owing to the coupling effect. The results show that the designed optical-fibre MIM plasmonic sensor could flexibly tune the number of Fano resonances by adjusting the structure and geometric parameters to optimise the sensing performance. The full width at half maximum of the Lorentzian resonance spectra formed by the electric and magnetic fields reached 23 nm and 24 nm, respectively. The wavelength of the Fano resonance shifted as the refractive index changed; thus, the proposed sensor could realise the application of sensing and detection. The highest sensitivity achieved by the sensor was 1770 nm/RIU. Finally, we simulated the designed sensor to human blood-glucose-level detection, and observed that the resonance wavelength would increase with the increase of glucose concentration. Our study shows that optical fibres have broad application prospects in the field of electromagnetic switching and sensing.

Terahertz (THz) metamaterials for rapid label-free sensing show application potential for the detection of cancer biomarkers. A novel flexible THz metamaterial biosensor based on a low refraction index parylene-C substrate is proposed. The biomarkers are modified on non-metal areas by a three-step modification method that simplifies the modification steps and improves the modified effectivity. Simulation results for non-metal modification illustrate that a bulk refractive index sensitivity of 325 GHz/RIU is achieved, which is larger than that obtained for the traditional metal modification (147 GHz/RIU). Meanwhile, several fluorescence experiments proved the uniform modification effect and selective adsorption capacity of the non-metal modification method. The concentration of the carcinoembryonic antigen (CEA) biomarkers for breast cancer patients tested using this THz biosensor is found to be consistent with results obtained from traditional clinical tests. The limit of detection reaches 2.97 ng/mL. These findings demonstrate that the flexible THz metamaterial biosensor can be extensively used for the rapid detection of cancer biomarkers in the future.

Refractive index (RI) sensing plays an important role in analytical chemistry, medical diagnosis, and environmental monitoring. The optofluidic technique is considered to be an ideal tool for RI sensor configuration for its high integration, high sensitivity, and low cost. However, it remains challenging to achieve RI measurement in real time with high sensitivity and low detection limit (DL) simultaneously. In this work, we design and fabricate a RI sensor with an arched optofluidic waveguide by monitoring the power loss of the light passing through the waveguide, which is sandwiched by the air-cladding and the liquid-cladding under test, we achieve RI detection of the sample in real time and with high sensitivity. Furthermore, both numerical simulation and experimental investigation show that our RI sensor can be designed with different geometric parameters to cover multiple RI ranges with high sensitivities for different applications. Experimental results illustrate that our sensor is capable to achieve a superior sensitivity better than −19.2 mW/RIU and a detection limit of 5.21×10−8 RIU in a wide linear dynamic range from 1.333 to 1.392, providing a promising solution for real-time and high-sensitivity RI sensing.

Helical twist provides an additional degree of freedom for controlling light in optical waveguides, expanding their applications in sensing. In this paper, we propose a helical broken-circular-symmetry core microstructured optical fiber for refractive index sensing. The proposed fiber consists of pure silica and its noncircular helical core is formed by a broken air ring. By using finite element modeling combined with transformation optics, the modal characteristics of the fiber are investigated in detail. The results show that for the core located at the fiber center, the confinement loss of fundamental core modes increases with twist rate, whereas for a sufficiently large core offset the modes can be well confined owing to the twist-induced light guidance mechanism, showing decreases with rising twist rate in the loss spectra. Moreover, we have found that for large twist rates and core offsets, resonant peaks occur at different twist rates due to the couplings between the fundamental core modes and the highly leaky modes created by the helical structure. The refractive index sensing performance is also studied and the obtained results show that the proposed fiber has great potential in fiber sensing.

This study successfully implements spectrally distinguishable CdSe-ZnS core–shell colloidal quantum dot (CQD) microlasers by a simple, efficient spray printing technique and demonstrates its potential in biosensing. We have systematically characterized the optical properties of printed microring lasers with diameters less than 60 µm. The smallest structure that can be excited has a diameter as small as 30 µm, which is much smaller than the counterparts prepared by piezoelectric ink-jet printing. The detection sensitivity of 4.54 nm/min/refractive index unit is verified in glucose sensing using a printed CQD microlaser. Biosensing of diverse glucose and bovine serum albumin solutions using printed microlasers with the assistance of defects demonstrates a new, to the best of our knowledge, prototype for the development of high-performance, low-cost on-chip microcavity sensors.

Parenteral artificial nutrition (PAN) is a lifesaving treatment for a large population of patients affected by different diseases, and it consists of intravenous injection of nutritive fluids by means of infusion pumps. Wrong PAN solutions are, unfortunately, often administered, thus threatening the patients’ well-being. Here, we report an optofluidic label-free sensor that can distinguish PAN solutions on the basis of their volumetric refractive index (RI). In our system, a monochromatic light beam, generated by a laser diode, travels obliquely through a transparent, square-section polystyrene channel, is then back-reflected by a mirror, and finally exits the channel in a position that depends on the filling fluid RI. The displacement of the output light spot ΔXexperim is easily detected with a linear, 1-D position sensitive detector (PSD). We initially calibrated the sensor with water-glucose solutions demonstrating a sensitivity S = ΔXexperim/Δn = 13,960 µm/RIU. We then clearly distinguished six commercial PAN solutions, commonly administered to patients. To the best of our knowledge, this is the first reported healthcare sensing platform for remote contactless recognition of PAN fluids, which could be inserted into infusion pumps to improve treatment safety, by checking the compliance to the prescription of the fluid actually delivered to the patient.

The paper proposes an ultra-narrow band graphene refractive index sensor, consisting of a patterned graphene layer on the top, a dielectric layer of SiO2 in the middle, and a bottom Au layer. The absorption sensor achieves the absorption efficiency of 99.41% and 99.22% at 5.664 THz and 8.062 THz, with the absorption bandwidths 0.0171 THz and 0.0152 THz, respectively. Compared with noble metal absorbers, our graphene absorber can achieve tunability by adjusting the Fermi level and relaxation time of the graphene layer with the geometry of the absorber unchanged, which greatly saves the manufacturing cost. The results show that the sensor has the properties of polarization-independence and large-angle insensitivity due to the symmetric structure. In addition, the practical application of testing the content of hemoglobin biomolecules was conducted, the frequency of first resonance mode shows a shift of 0.017 THz, and the second resonance mode has a shift of 0.016 THz, demonstrating the good frequency sensitivity of our sensor. The S (sensitivities) of the sensor were calculated at 875 GHz/RIU and 775 GHz/RIU, and quality factors FOM (Figure of Merit) are 26.51 and 18.90, respectively; and the minimum limit of detection is 0.04. By comparing with previous similar sensors, our sensor has better sensing performance, which can be applied to photon detection in the terahertz band, biochemical sensing, and other fields.

A fiber sensor based on a silica capillary in a balloon-like shape for simultaneous measurement of displacement and temperature is proposed and experimentally demonstrated. The sensor is fabricated by splicing a segment of a hollow-core fiber between two single-mode fibers (SMF) and by creating a balloon shape with the capillary at the top-center position. The SMF–capillary–SMF configuration excites an antiresonant (AR) guidance, and the balloon shape enhances the Mach–Zehnder interferometer (MZI). Experimental results show that, for a balloon length of 4.0 cm and a capillary length of 1.2 cm, the AR is insensitive to displacement and its sensitivity to temperature is 14.3 pm/°C, while the MZI has a sensitivity to displacement of 1.68 nm/mm in the range between 0 and 5 mm and a sensitivity to temperature of 28.6 pm/°C, twice the value of the AR. The proposed fiber sensor has only one sensing element in one configuration, which makes it simple to fabricate as well as low cost.

When developing oil fields, there is an urgent task to quickly determine the type of pumped formation fluid, which includes formation gas, formation oil and formation water. In this paper, we propose a new type of a sensor element designed for flow refractometry of formation fluid based on the effect of total internal reflection. The sensor element is a taper tip of a conical shape made of sapphire and is 20 mm in length and 20 mm in diameter. The original shape of the sensor element is determined by a modified ray tracing method, taking into account analytical relations that determine the conditions for providing a larger dynamic range of measurements under specified physical, technological and design constraints. The conversion dependence of the tip is obtained for the wavelengths of 405 nm, 1064 nm and 3300 nm and allows determining the type of formation fluid (gas/water/oil). The proposed method enables the development of conical sensor elements based on the total internal reflection for downhole monitoring systems and optical threshold sensors of the refractive index.

Optical microfiber-based refractometer, which relies on modal interference operating near the dispersion turning point (DTP), has attracted a high level of research interest. The ultrahigh sensitivity can be achieved by mitigating the group effective refractive index difference between the modes in the coupling. Through modifying the microfiber diameter, the group effective refractive index difference can be modified to zero which is defined as DTP. However, all the DTP-based sensors report low fabrication tolerance and narrow operation bandwidth of probing wavelength for the high-sensitivity region where the refractive index (RI) sensitivities higher than 104 nm/RIU can be achieved, which extremely limits the practical applications. To address the challenge, we manipulate and optimize the mode dispersion by using a tapered specially-designed single stress-applying fiber (SSAF). By introducing the stress-applying part (SAP) into the cladding, the wavelength sensitivity of the group effective RI difference can be significantly reduced through the flexibly engineerable control over the material index. In this way, the operation bandwidth is dramatically broadened for 500 nm in comparison with that of conventional microfiber with the same diameter based on DTP, indicating a broad range of optional probing wavelength and high fabrication tolerance. We experimentally verify the ultrahigh sensitivity and broadband operation around the DTP using an SSAF-based microfiber with a waist diameter of about 2.3 μm. The maximum RI sensitivity of 30563 nm/RIU is obtained.

In this work, the splitting of resonance lines in a Fabry-Perot resonator formed by a section of a standard curved single-mode fiber with metal-coated ends is investigated numerically and experimentally. It is shown that this splitting is similar to the Autler-Townes splitting and results from a strong coupling between the fundamental mode of the core and the whispering gallery mode of the cladding of the curved fiber. The influence of all basic parameters of the curved resonator on the splitting of its resonance lines in the reflection and transmission spectra is considered. Prospects for the practical application of the effects studied for high-resolution optical refractometry, as well as the direction of further research are outlined.

To improve the detection sensitivity of a porous silicon optical biosensor in the real-time detection of biomolecules, a non-spectral porous silicon optical biosensor technology, based on dual-signal light detection, is proposed. Double-light detection is a combination of refractive index change detection and fluorescence change detection. It uses quantum dots to label probe molecules to detect target molecules. In the double-signal-light detection method, the first detection-signal light is the detection light that is reflected from the surface of the porous silicon Bragg mirror. The wavelength of the detection light is the same as the wavelength of the photonic band gap edge of the porous silicon Bragg mirror. CdSe/ZnS quantum dots are used to label the probe DNA and hybridize it with the target DNA molecules in the pores of porous silicon to improve its effective refractive index and enhance the detection-reflection light. The second detection-signal light is fluorescence, which is generated by the quantum dots in the reactant that are excited by light of a certain wavelength. The Bragg mirror structure further enhances the fluorescence signal. A digital microscope is used to simultaneously receive the digital image of two kinds of signal light superimposed on the surface of porous silicon, and the corresponding algorithm is used to calculate the change in the average grey value before and after the hybridization reaction to calculate the concentration of the DNA molecules. The detection limit of the DNA molecules was 0.42 pM. This method can not only detect target DNA by hybridization, but also detect antigen by immune reaction or parallel biochip detection for a porous silicon biosensor.

In this work, a simple side-polish plastic optical fiber (POF)-based surface plasmon resonance (SPR) sensor is proposed and demonstrated for simultaneous measurement of refractive index (RI) and liquid level. The effects of side-polish depths on the sensing performance were studied. The experimental results show that the SPR peak wavelength will be changed as the RI changes, and the SPR peak intensity will be changed with the liquid level variation. By monitoring the changes in peak wavelength and intensity, the RI and liquid level can be detected simultaneously. Experimental results show that an RI sensitivity of 2008.58 nm/RIU can be reached at an RI of 1.39. This sensor has the advantages of simple structure and low cost, which has a good prospect in the field of biochemical sensing.

Optical fiber Fabry–Perot sensors have long been the focus of researchers in sensing applications because of their unique advantages, including highly effective, simple light path, low cost, compact size, and easy fabrication. Microcantilever-based devices have been extensively explored in chemical and biological fields while the interrogation methods are still a challenge. The optical fiber probe microcantilever sensor is constructed with a microcantilever beam on an optical fiber, which opens the door for highly sensitive, as well as convenient readout. In this review, we summarize a wide variety of optical fiber probe microcantilever sensors based on Fabry–Perot interferometer. The operation principle of the optical fiber probe microcantilever sensor is introduced. The fabrication methods, materials, and sensing applications of an optical fiber probe microcantilever sensor with different structures are discussed in detail. The performances of different kinds of fiber probe microcantilever sensors are compared. We also prospect the possible development direction of optical fiber microcantilever sensors.

Nanograting-based plasmonic sensors are capable of real-time and label-free detection for biomedical applications. Simple and low-cost manufacturing methods of high-quality sensors are always demanding. In this study, we report on a one-step etch-free method achieved by directly patterning a photoresist on a copper substrate using laser interference lithography. Large area uniform gratings with a period of 600 nm were fabricated on the copper film, and its refractive index sensing performance was tested using glucose as analyte. By replacing the metallic grating ridges with photoresist ridges, the Ohmic absorption and radiative scattering losses of surface plasmons were greatly reduced. As a result, a much sharper resonance linewidth (∼ 10 nm) was experimentally obtained. Compared with pure metallic gratings, the reported structure is characterized by sharper resonance and a much easier fabrication process, making it a cost-effective plasmonic sensor with high quality.

Reconstructive micro-spectrometers have shown great potential in many fields such as medicine, agriculture, and astronomy. However, the performance of these spectrometers is seriously limited by the spectral varieties of response pixels and anti-noise ability of reconstruction algorithms. In this work, we propose a spectral reconstruction (SR) algorithm, whose anti-noise ability is at least four times better than the current algorithms. A micro-spectrometer is realized by fabricating a large number of Fabry–Perot (FP) micro-filters onto a cheap complementary metal-oxide semiconductor (CMOS) chip for demonstration by using a very high-efficiency technology of nano-imprinting. Nano-imprint technology can complete hundreds of spectral pixels with rich spectral features at one time and with low cost. In cooperation with the SR algorithm, such a micro-spectrometer can have a spectral resolution as high as 3 nm with much lower angular sensitivity than a photonic crystal-based micro-spectrometer. It can obtain the target's spectrum from only a single shot, which has wide applications in spectral analysis etc.

Precise and accurate measurements of the optical refractive index (RI) for liquids are increasingly finding applications in biochemistry and biomedicine. Here, we demonstrate a dual-resonance helical long-period fiber grating (HLPFG) near the dispersion turning point (DTP), which exhibits an ultrahigh RI sensitivity (∼25546 nm/RIU at ∼1.440). The achieved RI sensitivity is, to the best of our knowledge, more than one order of magnitude higher than a conventional HLPFG. The ultrahigh RI sensitivity can improve the RI measurement precision and accuracy significantly. Furthermore, ultralow wavelength shifts (nearly zero) with temperature and strain ranging from 20 to 100°C and 0 to 2226 µε, respectively, are also demonstrated for the proposed HLPFG, which may be a good candidate for developing new low-cross-talk sensors.

A time-integration imaging polarimeter with continuous rotating retarder is presented, and its full-Stokes retrieving and configuration optimization are also demonstrated. The mathematical expression between the full-Stokes vector and the time-integration light intensities is derived. As a result, the state of polarization of incident light can be retrieved by only one matrix calculation. However, the modulation matrix deviates from the initial well-conditioned status due to time integration. Thus, we re-optimize the nominal angles for the special retardance of 132° and 90° with an exposure angle of 30°, which results in a reduction of 31.8% and 16.8% of condition numbers comparing to the original configuration, respectively. We also give global optimization results under different exposure angles and retardance of retarder; as a result, the 137.7° of retardance achieves a minimal condition number of 2.0, which indicates a well-conditioned polarimeter configuration. Besides, the frame-by-frame algorithm ensures the dynamic performance of the presented polarimeter. For a general brushless DC motor with a rotating speed of over 2000 rounds per minute, the speed of polarization imaging will achieve up to 270 frames per second. High precision and excellent dynamic performance, together with features of compactness, simplicity, and low cost, may give this traditional imaging polarimeter new life and attractive prospects.

We present a numerical and experimental study of resonance splitting in the transmission and reflection spectra of the Fabry–Perot resonator made of a bent section of a conventional single-mode optical fiber with metallized end faces. We show the splitting to be similar in nature to the well-known Autler–Townes effect and to arise from the strong coupling between the core mode and cladding whispering gallery mode of the bent fiber. The effect of all major parameters of the bent resonator on the splitting of its resonances is demonstrated. Potential applications of the observed effects in the field of precision optical refractometry as well as further research directions are discussed.

We propose and experimentally demonstrate a highly flexible and applicable configuration, namely, the “ v ertical-fluid-array i nduced o ptic microfiber l ong per i od grati n g” (VIOLIN), for fully exploring the characteristics of liquids. The presence of flowing liquid in the periodically carved grooves of the designated substrate can activate a long-period grating resonance, as the microfiber is attached. Since the features of the resonance depend strongly on the refractive index of the fluid, the VIOLIN can be utilized as a refractometer with a high sensitivity of 2443 nm/RIU. Modeling and simulation are employed to investigate the mechanism of the sensor, which can be described as follows briefly: “Liquid renders the resonance to light. Light deciphers the secret of liquid.” Moreover, due to the highly elastic control of the fluidic array and the detachable configuration, multiple sensing and easy reconfiguration of the VIOLIN can be realized. The VIOLIN is expected to be highly suitable for microfiber-based chemo/biosensing applications.

A novel refractometer based on multimode fiber (MMF) embedded single mode-no core-single mode (ME-SNS) fiber structure is presented and investigated in detail. The ME-SNS structure has a higher refractive index (RI) sensitivity because of the stronger evanescent field generated by RI modulation. There is an obvious attenuation dip when 3 segment MMFs are embedded in single mode-no core-single mode (SNS) fiber structure. Total length of sensing unit is only 1.8 mm. Experimental results show that the maximal RI and the temperature sensitivity of the ME-SNS fiber structure are 567.158 nm/RIU and 0.009 nm/°C.

This letter reports a novel fused silica microfluidic device with pressure sensing capability that is fabricated by integrated additive and subtractive manufacturing (IASM) method. The sensor consists of a capillary and a 3D printed glass reservoir, where the reservoir volume change under pressure manifests liquid level deviation inside the capillary, thus realizing the conversion between small pressure change into large liquid level variation. Thanks to the design flexibility of this unique IASM method, the proposed microfluidic device is fabricated with liquid-in-glass thermometer configuration, where the reservoir is sealed following a novel 3D printing assisted glass bonding process. And liquid level is interrogated by a fiber-optic sensor based on multimode interference (MMI) effect. This proposed microfluidic device is attractive for chemical and biomedical sensing because it is flexible in design, and maintains good chemical and mechanical stability, and adjustable sensitivity and range.

To date, there is clear experimental evidence that gold-coated tilted fiber Bragg gratings (TFBGs) are highly sensitive plasmonicbiosensors that provide temperature-compensated detection of analytes at concentrations in the picomolar range. Asmost optical biosensors, they bring an evanescent wave in the surrounding medium, which makes them sensitive to both surface refractive index variations (= the useful biosensing signal) and to bulk refractive index changes (= the non-useful signal forbiosensing). This dual sensitivity makes them prone to drift. In this work, we study partially gold-coated TFBGs around theircross-section. These gratings present the ability to discriminate both volume and surface refractive index changes, which isinteresting in biosensing to enhance the signal-to-noise ratio. The effects induced in the TFBGs transmitted amplitude spectrawere analyzed for surrounding refractive index (SRI) changes in the range 1.3360–1.3370. Then, the gold film wasbiofunctionalized with human epidermal growth factor receptor (HER2) aptamers using thiol chemistry. The detection of HER2proteins (a relevant cancer biomarker) at 10−9g/mL, 10−8g/mL and 10−6g/mL demonstrated the advantage toidentifyenvironmental perturbations through the bare area of the TFBGs, which is left not functionalized. The non-specific driftsthatcould exist in samples are eliminated and a wavelength shift only related to the surface modification is obtained.&nbsp

The presence of species other than the target biomolecules in the fluidic analyte used in the refractive index biosensor based on the surface plasmon resonances (SPRs) can lead to measurement ambiguity. Using graphene-based acousto-plasmonic biosensors, we propose two methods to eliminate any possible ambiguity in interpreting the measured results. First, we take advantage of the dynamic tunability of graphene SPRs in the acousto-plasmonic biosensor with a surface acoustic wave (SAW) induced uniform grating, performing measurements at different applied voltages. Second, a single measurement employing a similar biosensor but with SAW-induced dual-segment gratings. The numerical results show the capability of both methods in decoupling the effect of the target analyte from the other species in the fluid, enabling interpreting the measurement results with no ambiguity. We also report the results of our numerical investigation on the effect of measuring parameters like the target layer effective refractive index and thickness, and the fluid effective refractive index, in addition to the controlling parameters of the proposed acousto-plasmonic biosensor, including graphene Fermi energy and electrical signaling on the sensing characteristics. Both types of proposed biosensors show promising features for developing the next generation lab-on-a-chip biosensors with minimal cross-sensitivities to non-target biomolecules.

The soluble solids content (SSC) is an important factor in the internal quality detection of apples. It is essential to have reliable and high-speed measurement of the SSC. However, almost all traditional equipment is inconvenient and expensive. We designed a handheld nondestructive SSC detector based on near-infrared (NIR) spectroscopy, which is composed of a portable NIR spectrometer, cloud server, smartphone app, and prediction model of SSC. We preprocessed the spectrum with multiplicative scatter correction (MSC), standard normal variable transformation (SNV), and Savitzky–Golay (S–G) smoothing algorithms. Besides, the linear weight reduction of the particle swarm optimization algorithm is carried out, and we establish the model of an extreme learning machine optimized with the improved particle swarm optimization (IPSO-ELM) algorithm. The R 2 , root mean square error of prediction (RMSEP), and residual prediction deviation (RPD) of the model are 0.993, 0.0155, and 11.6, respectively, which are better than the traditional model obviously. In addition, the number of wavelengths reduced from 228 to 70 as the model is simplified with the uninformative variable elimination (UVE) method. The time of training is reduced by 29.30% compared with the original spectrum. It can be verified that the IPSO-ELM model has good prediction performance, and the NIR diffuse reflectance spectroscopy is a reliable nondestructive measurement of SSC in apples.

The article considers the potential applicability of C12880MA and C11708MA Hamamatsu microspectrometers, which are characterized by an extremely compact design, occupying a small volume of several cubic centimeters, in portable spectrometric equipment with spatial resolution for monitoring the optical properties of condensed scattering media. The development of methods for determining the reduced scattering and absorption spectral coefficients of radiation from various scattering materials and products allows us to speak about the possibility of real-time control of the volume concentration of optically active components included in them, for example, fat and water in dairy products. For this, it is necessary to provide sufficiently accurate spectra of diffusely reflected broadband light radiation at different distances between the points of radiation entrance and registration. The aim of the manuscript is to assess the possibility of using the considered microspectrometers in compact devices for optical diagnostics and control of the optical properties of condensed scattering media. The features of the connection diagram of these microspectrometers and the necessary methods for correcting the initially obtained spectral dependencies of diffusive reflection, which will be of interest to developers of spectral diagnostic equipment, are considered in detail. The need to eliminate the influence of the inhomogeneity of dark counts of a CMOS photodiode array is shown. The hardware functions of the C12880MA and C11708MA Hamammatsu microspectrometers, as well as the AvaSpec 2048L fiber-optic spectrometer, were experimentally measured and compared. Methods for correcting the nonlinearity of their reading scales and light characteristics, as well as improving their equivalent spectral resolution using digital Wiener filtering, are described. It is shown that the equivalent spectral resolution of C12880MA and C11708MA microspectrometers can be improved by about 40% when recording smooth spectra, subject to the condition that the resulting side oscillations are small. It is pointed out that in order to reduce the level of side oscillations in the corrected spectra with improved resolution, it is necessary to ensure the smoothness of the original spectra and a good signal-to-noise ratio. A conclusion is made about the possibility of using the considered microspectrometers in portable spectrometric equipment with careful consideration of their characteristics, the features of their switching circuit, and the necessary software.

Carbon monoxide (CO) is a highly toxic gas, which can cause death if it is inhaled in small quantities for a long time or in large quantities for a short time. Since this gas can be lethal, it is essential to detect it from minute to large concentrations. Our study consists of the design of a superficial plasmonic resonance (SPR) CO sensor of tiny dimensions which is capable of giving an immediate response at different concentrations. It is designed to work at different heights above sea level since the refractive index of this gas depends on a mixture with air and the air pressure. Due to its low weight and tiny dimensions, it is ideal for space travel or on airplanes. The results show a high resolution and sensitivity (~10−5 RIU of resolution and a sensitivity of 13.51–81.26 RIU−1).

In this research work, an anisotropic photonic crystal fiber (PCF) biosensor working on a refractive index (RI) variation and based on surface plasmon resonance (SPR) is presented. Liquid analytes (LA) having a RI within the range of 1.340 to 1.380 RIU are investigated from the proposed biosensor. Spectroscopy analysis of LA having RI values of 1.340 RIU, 1.360 RIU, and 1.380 RIU is performed from the developed sensing setup for modeling an ultrasensitive biosensor. The numerical analysis of the sensing parameters for the proposed sensor presents a maximum wavelength sensitivity (WS) of 20000 nm/RIU for x- polarization (x − pol.) and 18000 nm/RIU for y- polarization (y − pol.), respectively, using the wavelength interrogation technique. Maximum amplitude sensitivity (AS) of 2158 RIU−1 and 3167 RIU−1 is obtained for x − pol. and y − pol., respectively, using the amplitude interrogation technique. Maximum sensor resolution (SR) of 5.00 × 10−6 RIU and 5.55 × 10−6 RIU is obtained for x − pol. and y − pol., respectively. The linear relationship of the resonant wavelength (RW) with the RI produces R2 = 0.9972 and R2 = 0.9978, corresponding to a degree (2) for x − pol. and y − pol., respectively. The figure of merit (FOM) for x − pol. and y − pol. are 93.45 RIU−1 and 105.88 RIU−1, respectively. The sensing parameters have obtained the maximum value for the LA having a RI value of 1.375 RIU.

This work demonstrates an interferometric technique to measure the refractive index (RI) of microliter volume of biosample solutions with the help of an optical fiber negative axicon and Bessel beam with the micrometer-size central spot. The RI measuring device consists of a broadband superluminescent diode (SLD) source along with an optical circulator and spectrometer. The axicon optical fiber probe packaged with a glass slide is connected to a broadband SLD source through an optical circulator, and a drop of microliter bioliquid sample is placed on the packaged probe’s head. The reflected light from the glass–liquid interface couples back to the axicon probe and interferes with the reference beam generated at the air–glass interface of the axicon. The interference spectrum is further analyzed by applying the fast Fourier transform to calculate power from the respective interface and solve the Fresnel equation for the RI measurement. The RI of small sample volume ∼ 2 µ l of glucose solutions and bovine serum albumin protein solutions are reported as an application of the proposed method. This sensing platform shows promising applications in biomedicine for monitoring small volume various biosample concentrations. We also demonstrate RI measurement of flowing liquid sample using the developed setup in case the design can be considered for microfluidic channel research.

The interaction between the terahertz wave propagating in free space and the sample is weak, which leads to the weak signal of the sample, which cannot meet the detection needs of trace samples. In order to meet the detection of trace samples, a kind of metamaterial absorber (the basic unit of the absorber is composed of gold-high resistance silicon-aluminum three-layer structure) is designed, and the monolayer graphene is transferred on the surface of the metamaterial absorber to construct the graphene-metamaterial absorber heterostructure. The transmission spectrum of the resonant cavity is simulated and measured by terahertz time domain spectroscopy system, and the obvious resonance frequency shift is observed. The results show that the graphene-metamaterial absorber heterostructure can detect josamycin antibiotic solution with concentration of 0.02 mg/L (the mass of josamycin is 0.2 ng). Compared with using the same structure metamaterial absorber to detect josamycin antibiotics, the sensitivity is increased by an order of magnitude. Using graphene-metamaterial heterostructure to detect the relative change of heterostructure reflectivity caused by josamycin antibiotics can reach 40%. The research in this paper provides a new technical means for accurate and rapid detection in terahertz band.

A dynamic spectroscopic imaging ellipsometer (DSIE) employing a monolithic polarizing interferometer is described. The proposed DSIE system can provide spatio-spectral ellipsometric phase map data Δ(λ, x) dynamically at a speed of 30 Hz. We demonstrate the ultrafast mapping capability of the spectroscopic ellipsometer by measuring a patterned 8-inch full wafer with a spatial resolution of less than 50 × 50 µm2 in an hour.

Multiple parameters need to be monitored to analyze the kinetics of biological progresses. Surface plasmon polariton resonance sensors offer a non-invasive approach to continuously detect the local change of refractive index of molecules with high sensitivity. However, the fabrication of miniaturized, compact, and low-cost sensors is still challenging. In this paper, we propose and demonstrate a grating-coupled SPR sensor platform featuring dual mode operation for simultaneous sensing of pressure and refractive index, which can be fabricated using a highly-efficient low-cost method, allowing large-scale production. Both sensing functionalities are realized by optical means via monitoring the spectral positions of a surface plasmon polariton mode (for refractive index sensing) and Fabry-Perot or metal-insulator-metal modes (for pressure sensing), which are supported by the structure. Simultaneous measurement of refractive index with the sensitivity of 494 nm/RIU and pressure was demonstrated experimentally. The proposed platform is promising for biomonitoring that requires both high refractive index sensitivity and local pressure detection.

We propose an all-dielectric asymmetric ring-cylindrical metasurface. Based on the analysis of transmission characteristics and the calculation of electromagnetic field distribution of the metasurface with this element structure, it is found that the high Q resonance of the ultra-narrowband can be realized when the symmetry of the ring-cylindrical structure is broken. Meanwhile, it is found that the degree of asymmetry of the ring, the refractive index of the material, the radius of the ring, and the substrate have great influence on the Q value and resonant frequency of the metasurface. Our proposed metasurface structure is applied to the detection of biological molecules based on the change in refractive index of biomolecular solutions. The designed metasurface with high sensitivity to detect biomolecules with different refractive indices, the Q value can reach 365.03, and the sensitivity is increased by 90.36 GHz/RIU compared to that without substrate, while the figure of merit value is as high as 100.56, providing label-free detection of biomolecules.

We investigated the feasibility of a simple effective refractive index model based on the finite-difference time-domain method for DNA self-assembled metamolecules. Metamolecules were fabricated with Au nanoparticles (AuNPs) and a two-layer rectangular DNA template. Simulated scattering spectra for AuNPs placed on the template (neff = 1.3), self-assembled DNA dimers (neff = 1.34), and quadrumers (neff = 1.5) matched well with experimental results. Dipolar and Fano-like resonances were predicted from the calculated field distribution. These results indicate that we can easily estimate the resonance mode of fabricated metamolecules on a glass substrate, even when they are surrounded by complex materials such as DNA, by using a simple refractive index model.

In this study, the silver mirror reaction was used to coat the silver film on the surface of self-made microstructured fiber (MSF) to stimulate the surface plasmon resonance effect, and Polydimethylsiloxane (PDMS) with a high thermal-optical coefficient was coated on the silver film as temperature-sensitive material. The MSF with silver and PDMS films was coupled with multi-mode fiber on both sides to form the temperature sensor. In this sensor system, the energy is coupled into the cladding of the microstructure fiber by multi-mode fiber, and the surface plasmon resonance can be further excitated in the MSF. When the temperature of the external environment changes, the refractive index of PDMS will also change. At this time, combined with the surface plasmon resonance effect, a resonant absorption peak corresponding to the temperature appears in the transmission spectrum so that the temperature can be measured quickly and accurately. We found that, in the temperature range of 35 °C to 95 °C, the average temperature sensitivity of the sensor during heating and cooling was −0.83 nm/°C and −0.84 nm/°C, respectively. The advantages of this sensor are the simple structure, convenient operation and good reversibility. The relative sensitivity deviation value (RSD = 0.0059) showed that the sensor has high stability. The temperature sensor based on MSF has favorable prospects for use in fields such as medical treatment, biochemical detection and intelligent monitoring.