4 results on '"Brancaccio, Raffaele"'
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2. Quality of life in patients with allergic and immunologic skin diseases: in the eye of the beholder
- Author
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Di Agosta, Ester, Salvati, Lorenzo, Corazza, Monica, Baiardini, Ilaria, Ambrogio, Francesca, Angileri, Luisa, Antonelli, Elettra, Belluzzo, Federica, Bonamonte, Domenico, Bonzano, Laura, Brancaccio, Raffaele, Custurone, Paolo, De Marco, Aurora, Detoraki, Aikaterini, Di Guida, Adriana, Di Leo, Elisabetta, Fantò, Marta, Fassio, Filippo, Ferrucci, Silvia Mariel, Foti, Caterina, Gallo, Rosella, Gatta, Alessia, Guarneri, Fabrizio, Guidolin, Lucia, Hansel, Katharina, Lamacchia, Donatella, Lombardo, Carla, Minciullo, Paola Lucia, Napolitano, Maddalena, Pannofino, Alessandro, Paravisi, Andrea, Parente, Roberta, Passante, Maria, Patruno, Cataldo, Peroni, Diego, Quecchia, Cristina, Schettini, Natale, Spadaro, Giuseppe, Stingeni, Luca, Tarrini, Daniele, Tramontana, Marta, Nettis, Eustachio, and Rossi, Oliviero
- Published
- 2021
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3. miRNAs' Cross-Involvement in Skin Allergies: A New Horizon for the Pathogenesis, Diagnosis and Therapy of Atopic Dermatitis, Allergic Contact Dermatitis and Chronic Spontaneous Urticaria.
- Author
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Brancaccio, Raffaele, Murdaca, Giuseppe, Casella, Rossella, Loverre, Teresa, Bonzano, Laura, Nettis, Eustachio, and Gangemi, Sebastiano
- Subjects
URTICARIA ,ATOPIC dermatitis ,CONTACT dermatitis ,MICRORNA ,ALLERGIES ,DIAGNOSIS - Abstract
Skin inflammation is a common underlying feature of atopic dermatitis, allergic contact dermatitis and chronic spontaneous urticaria. The pathogenetic mechanisms have not been fully elucidated. The purpose of this study was to examine whether miRNA, by regulating inflammatory mechanisms through the modulation of innate and adaptive immune responses, could play a major role in the pathogenesis of these skin conditions. We conducted a narrative review using the Pubmed and Embase scientific databases and search engines to find the most relevant miRNAs related to the pathophysiology, severity and prognosis of skin conditions. The studies show that miRNAs are involved in the pathogenesis and regulation of atopic dermatitis and can reveal an atopic predisposition or indicate disease severity. In chronic spontaneous urticaria, different miRNAs which are over-expressed during urticaria exacerbations not only play a role in the possible response to therapy or remission, but also serve as a marker of chronic autoimmune urticaria and indicate associations with other autoimmune diseases. In allergic contact dermatitis, miRNAs are upregulated in inflammatory lesions and expressed during the sensitization phase of allergic response. Several miRNAs have been identified as potential biomarkers of these chronic skin conditions, but they are also possible therapeutic targets. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
4. Quality of life in patients with allergic and immunologic skin diseases: in the eye of the beholder
- Author
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Ester Di Agosta, Lorenzo Salvati, Monica Corazza, Ilaria Baiardini, Francesca Ambrogio, Luisa Angileri, Elettra Antonelli, Federica Belluzzo, Domenico Bonamonte, Laura Bonzano, Raffaele Brancaccio, Paolo Custurone, Aurora De Marco, Aikaterini Detoraki, Adriana Di Guida, Elisabetta Di Leo, Marta Fantò, Filippo Fassio, Silvia Mariel Ferrucci, Caterina Foti, Rosella Gallo, Alessia Gatta, Fabrizio Guarneri, Lucia Guidolin, Katharina Hansel, Donatella Lamacchia, Carla Lombardo, Paola Lucia Minciullo, Maddalena Napolitano, Alessandro Pannofino, Andrea Paravisi, Roberta Parente, Maria Passante, Cataldo Patruno, Diego Peroni, Cristina Quecchia, Natale Schettini, Giuseppe Spadaro, Luca Stingeni, Daniele Tarrini, Marta Tramontana, Eustachio Nettis, Oliviero Rossi, Di Agosta, Ester, Salvati, Lorenzo, Corazza, Monica, Baiardini, Ilaria, Ambrogio, Francesca, Angileri, Luisa, Antonelli, Elettra, Belluzzo, Federica, Bonamonte, Domenico, Bonzano, Laura, Brancaccio, Raffaele, Custurone, Paolo, De Marco, Aurora, Detoraki, Aikaterini, DI GUIDA, Adriana, Di Leo, Elisabetta, Fantò, Marta, Fassio, Filippo, Mariel Ferrucci, Silvia, Foti, Caterina, Gallo, Rosella, Gatta, Alessia, Guarneri, Fabrizio, Guidolin, Lucia, Hansel, Katharina, Lamacchia, Donatella, Lombardo, Carla, Lucia Minciullo, Paola, Napolitano, Maddalena, Pannofino, Alessandro, Paravisi, Andrea, Parente, Roberta, Passante, Maria, Patruno, Cataldo, Peroni, Diego, Quecchia, Cristina, Schettini, Natale, Spadaro, Giuseppe, Stingeni, Luca, Tarrini, Daniele, Tramontana, Marta, Nettis, Eustachio, and Rossi, Oliviero
- Subjects
Quality of life ,Hereditary angioedema ,Cutaneous mastocytosis ,Allergy ,Urticaria ,Allergic contact dermatitis ,Atopic dermatitis ,Skin ,Immunology ,Review ,RC581-607 ,humanities ,Immunology and Allergy ,Immunologic diseases. Allergy ,skin and connective tissue diseases ,Molecular Biology - Abstract
Allergic and immunologic skin diseases negatively impact the quality of life (QoL) of affected patients with detrimental consequences. Nonetheless, in everyday clinical practice the evaluation of QoL is often overlooked. Considering the increasing prevalence of atopic dermatitis, allergic contact dermatitis, hereditary angioedema, cutaneous mastocytosis, and urticaria, it is essential to determine the effects of allergic and immunologic skin diseases on QoL. A joint meeting (GET TOGETHER 2021) of the Italian Society of Allergology, Asthma and Clinical Immunology (SIAAIC) and the Italian Society of Allergological, Occupational and Environmental Dermatology (SIDAPA) aimed to summarize the features of the main QoL tools used in these diseases and to describe the extent of QoL impairment as well as the impact of treatments on QoL, particularly biologic therapies. The assessment of QoL in patients with allergic and immunologic skin diseases relies on generic, organ-specific and disease-specific questionnaires. While generic and organ-specific questionnaires allow comparison between different diseases, disease-specific questionnaires are designed and validated for specific cohorts: the QoL Index for Atopic Dermatitis (QoLIAD) and the Childhood Atopic Dermatitis Impact Scale (CADIS) in atopic dermatitis, the ACD-11 in allergic contact dermatitis, the Angioedema QoL Questionnaire (AE-QoL) and the Hereditary Angioedema QoL questionnaire (HAE-QoL) in hereditary angioedema, the Mastocytosis QoL Questionnaires (MCQoL e MQLQ) in cutaneous mastocytosis, and the Chronic Urticaria QoL questionnaire (CU-Q2oL) in urticaria. Among the many factors that variably contribute to QoL impairment, pruritus can represent the leading cause of patient discomfort. Biologic therapies significantly ameliorate QoL in atopic dermatitis, hereditary angioedema, mastocytosis and chronic urticaria. In general, adequate management strategies are essential for improving QoL in patients with allergic and immunologic skin diseases.
- Published
- 2021
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