1. Transient manifestation of left ventricular diastolic dysfunction following ablation in patients with paroxysmal atrial fibrillation.
- Author
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Minamisaka T, Watanabe T, Shinoda Y, Ikeoka K, Fukuoka H, Inui H, Ueno K, Inoue S, Mine K, and Hoshida S
- Subjects
- Aged, Atrial Fibrillation physiopathology, Diastole, Echocardiography, Female, Follow-Up Studies, Heart Ventricles diagnostic imaging, Humans, Male, Retrospective Studies, Tachycardia, Paroxysmal physiopathology, Ventricular Dysfunction, Left diagnosis, Ventricular Dysfunction, Left physiopathology, Atrial Fibrillation surgery, Catheter Ablation adverse effects, Electrocardiography, Heart Ventricles physiopathology, Postoperative Complications, Tachycardia, Paroxysmal surgery, Ventricular Dysfunction, Left etiology
- Abstract
Background: In patients with atrial fibrillation, ablation decreases left atrial (LA) compliance, which may lead to left ventricular (LV) diastolic dysfunction. We aimed to examine serial changes in LV diastolic function after 2 ablation procedures and their related factors in patients with paroxysmal atrial fibrillation (PAF)., Hypothesis: LV diastolic function is different after 2 ablation procedures., Methods: We enrolled 132 patients with PAF (76 males, mean age 67 years; cryoballoon [CB] ablation/radiofrequency [RF] ablation 60/72) who underwent a single ablation procedure. The transthoracic echocardiographic parameters were obtained before, 3 days after, and 6 months after ablation., Results: The afterload-related index of LV diastolic function, Ed/Ea = E/e' / (0.9 × systolic blood pressure), increased significantly at 3 days after ablation, especially after CB ablation (P <0.05), although no differences were observed in age, sex, LA size, LV size, and E/e' before ablation between CB ablation and RF ablation. Creatine kinase release after ablation was significantly higher in CB ablation than in RF ablation (P <0.001). The increment of Ed/Ea after CB ablation was positively correlated with LV ejection fraction (LVEF) before ablation (r =0.416; P <0.05). The elderly (age ≥ 75 years), females, and patients with hypertension were more likely to show impaired LV diastolic function transiently after 3 days of ablation, but the diastolic index was restored to baseline level after 6 months., Conclusions: The increased Ed/Ea after CB ablation represented transient manifestation of underlying LV diastolic dysfunction in PAF patients with preserved LVEF with older age, female sex, and a history of hypertension., (© 2018 Wiley Periodicals, Inc.)
- Published
- 2018
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