1. Exploratory Study on Visual Acuity and Patient-Perceived Visual Function in Patients with Subretinal Drusenoid Deposits
- Author
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Sarega Gurudas, Manjot Kaur Grewal, Sobha Sivaprasad, Alan C. Bird, Glen Jeffery, and Shruti Chandra
- Subjects
musculoskeletal diseases ,medicine.medical_specialty ,Visual acuity ,genetic structures ,lcsh:Medicine ,subretinal drusenoid deposits ,Article ,03 medical and health sciences ,0302 clinical medicine ,Atrophy ,Disease severity ,intermediate age related macular degeneration ,Ophthalmology ,Medicine ,In patient ,Healthy aging ,030304 developmental biology ,0303 health sciences ,business.industry ,low-luminance visual acuity ,lcsh:R ,General Medicine ,Macular degeneration ,medicine.disease ,retinal ageing ,eye diseases ,low-luminance deficit ,Geographic atrophy ,Visual function ,030221 ophthalmology & optometry ,sense organs ,medicine.symptom ,low-luminance questionnaire ,business - Abstract
Purpose: To investigate the value of visual acuity and patient-perceived visual function test when subretinal drusenoid deposits (SDD) are incorporated into the classification of age-related macular degeneration (AMD). A total of 50 participants were recruited into the study in these groups: healthy ageing (n = 11), intermediate AMD (iAMD) with no SDD (n = 17), iAMD with SDD (n = 11) and non-foveal atrophic AMD (n = 11) confirmed by two retinal imaging modalities. Best-corrected visual acuity (BCVA) and low luminance visual acuity (LLVA) were measured and low luminance deficit (LLD) was calculated. Participants were also interviewed with the low luminance questionnaire (LLQ). Linear regression was used to assess function&ndash, function relations. Compared with healthy participants, BCVA and LLVA scores were significantly reduced in the atrophic AMD group (p <, 0.0001 and p = 0.00016, respectively) and in patients with SDD (p = 0.028 and p = 0.045, respectively). Participants with atrophy also had reduced BCVA (p = 0.001) and LLVA (p = 0.009) compared with the iAMD no SDD group. However, there were no differences in visual function tests between healthy aging and iAMD without SDD and between iAMD with SDD and atrophic AMD groups. The LLD score did not differ between groups. BCVA and LLVA correlated well. The LLQ did not correlate with visual function tests. This study shows that LLD is not a marker of disease severity as assessed clinically. Although LLQ is a good marker for disease severity using the current AMD classification, it does not differentiate between eyes with and without SDD. Eyes with non-macular geographic atrophy and SDD had lower function than eyes with no SDD and healthy controls.
- Published
- 2020