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Introduction: For many decades, clinical and epidemiological associations between gynaecological illness and psychia- tric disorders have been reported. Thus, in recent years, special attention has been paid to the gynaecological health of women with chronic psychosis.We aimed to determine the rates of oestrogen and non-oestrogen dependent gynae- cological disorders in women diagnosed with delusional disorder (DwDD), and its relationship with clinical outcomes. Methods: We conducted a longitudinal and observational study in 90 women DwDD who attended our Department of Psychiatry, from 2000 until 2013. Subjects were selected by consecutive sampling and followed-up for one year. The presence or absence of inflammatory and non inflammatory-gynaecological disorders was recorded according to ICD-10 criteria, and attendance rates at appointments (psychiatric and nursing) were collected. For comparisons, T and Chi-square tests were performed. Multinomial logistic regression was applied to investigate multivariate differences. Results: Thirty-six (40%) women DwDD had a history of gynaecological disease (oestrogen dependent disorders: 36.7%). Women diagnosed with a gynaecological disease had higher unemployment rates than those without gynae- cological conditions ( p = .03). Patients without gynaecological disorders attended later our psychiatric service and were more frequently admitted ( p = .048). Within the gynaecological group, leiomyoma of uterus (n = 9; 10%) was the most common condition followed by misscarriage (n = 6; 6.7%). Hysterectomy (n = 7; 7.8%) was the most common surgical treatment. After one year, women diagnosed with gynaecological illness showed a tendency to lower rates of affective comorbidity and less antidepressant prescription. After controlling for age at first appointment and admissions, differences in affective comorbidity remained significant ( p = .020); however, differences in antidepressant prescription and employment status were no longer significant. Conclusions: Women DwDD might be at particular risk of non-inflammatory oestrogen dependent gynaecological disorders. The role of mental health nurses should be addressed to improve attendance rates at gynaecological appoint- ments and prevention programs.

Introduction Gender differences in attendance rates for appointments in delusional disorder have been poorly studied. Furthermore, delusional disorder is traditionally considered a treatment-resistant disorder. Material and methods We conducted a longitudinal retrospective study with a one-year follow-up, including 78 delusional disorder patients (DSM- IV -TR), consecutively admitted over a period of 10 years. We performed a follow-up for one year in order to describe demographic and clinical variables, and to compare the therapeutic effectiveness. In this study, due to the non-interventional nature of this study, indirect measures were used to measure treatment effectiveness. The sample was divided into three groups according to the antipsychotic received at the first admission. Results Twenty-three patients received Risperidone Long-Acting Injection (RILD), 30 oral risperidone, and 25 patients received other oral atypical antipsychotics. Delusional disorder women had a later age at onset and needed a longer duration of hospitalisation. No statistically significant differences were found between the three treatment groups as regards demographic data, social and personal functioning, and psychopathology at admission. The RILD group showed higher maintenance rates at the end of the follow-up period. Furthermore, the RILD group required treatment with antidepressants and benzodiazepines less often. Conclusions We concluded that treatment with RLAI may increase maintenance rates at follow-up in DD patients when compared with other oral atypical antipsychotics.