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Background: The objective of this study was to describe the perspective of patients with early breast cancer toward research biopsies. The authors hypothesized that more patients at academic sites than at community-based sites would be willing to consider these procedures., Methods: In total, 198 patients with early stage breast cancer were recruited from 3 academic centers (n = 102) and from 1 community oncology practice (n = 96). The primary objective was to compare the proportion of patients willing to consider donating excess tissue biospecimens from surgery, from a clinically indicated breast biopsy, or from a research purposes-only biopsy (RPOB) between practice types., Results: Most patients (93% at academic sites, 94% at the community oncology site) said they would consider donating excess tissue from surgery for research. One-half of patients from academic or community sites would consider donating tissue from a clinically indicated breast biopsy. On univariate analysis, significantly fewer patients from academic sites would consider an RPOB (22% at academic sites, 42% at the community site; P = .003); however, this difference was no longer significant on multivariate analysis (P = .96). Longer transportation times and unfavorable prior experiences were associated with less willingness to consider an RPOB on multivariate analysis. Significantly fewer patients from academic sites (14%) than from the community site (35%) would consider a research biopsy in a clinical trial (P = .04). Contributing to scientific knowledge, return of results, and a personal request by their physician were the strongest factors influencing patients' willingness to undergo research biopsies., Conclusions: The current results rejected the hypothesis that more patients with early breast cancer at academic sites would be willing to donate tissue biospecimens for research compared with those at community oncology sites. These findings identify modifiable factors to consider in biobanking studies and clinical trials., (© 2020 American Cancer Society.)

Less than one-fifth of the U.S. population consistently wears automobile seatbelts. Automatic seatbelts or air bags will be required in all new cars, unless States whose total population equals two-thirds of the nation's adopt mandatory seatbelt use laws by 1989, according to the U.S. Department of Transportation. In July 1984, New York State passed the first mandatory seatbelt law in the nation, followed by New Jersey, Illinois, Missouri, Michigan, and New Mexico. A telephone survey of 2,982 randomly selected drivers examined belt use and support for mandatory belt use laws in the six New England States. Drivers with little education and low income, younger drivers, and drivers who drove after heavy drinking or marijuana use, or both, were least likely to wear seatbelts. Beliefs that seatbelts are not effective in reducing injury risk and are uncomfortable were more common among those not wearing belts. Sixty percent of drivers favored a mandatory seatbelt use law. The most important predictors of opposition to a belt use law were beliefs that seatbelts are ineffective, inconvenient, and uncomfortable. Opposition was also more likely among persons who reported that they drove after marijuana use, or heavy drinking, or both, drove more miles per year, exhibited a low frequency of seatbelt use, and perceived a low probability of personal crash involvement.