8 results on '"Boubenec, Yves"'
Search Results
2. Dynamics and maintenance of categorical responses in primary auditory cortex during task engagement.
- Author
-
Chillale RK, Shamma S, Ostojic S, and Boubenec Y
- Subjects
- Animals, Ferrets, Sound, Behavior, Animal physiology, Acoustic Stimulation, Auditory Perception physiology, Auditory Cortex physiology
- Abstract
Grouping sets of sounds into relevant categories is an important cognitive ability that enables the association of stimuli with appropriate goal-directed behavioral responses. In perceptual tasks, the primary auditory cortex (A1) assumes a prominent role by concurrently encoding both sound sensory features and task-related variables. Here, we sought to explore the role of A1 in the initiation of sound categorization, shedding light on its involvement in this cognitive process. We trained ferrets to discriminate click trains of different rates in a Go/No-Go delayed categorization task and recorded neural activity during both active behavior and passive exposure to the same sounds. Purely categorical response components were extracted and analyzed separately from sensory responses to reveal their contributions to the overall population response throughout the trials. We found that categorical activity emerged during sound presentation in the population average and was present in both active behavioral and passive states. However, upon task engagement, categorical responses to the No-Go category became suppressed in the population code, leading to an asymmetrical representation of the Go stimuli relative to the No-Go sounds and pre-stimulus baseline. The population code underwent an abrupt change at stimulus offset, with sustained responses after the Go sounds during the delay period. Notably, the categorical responses observed during the stimulus period exhibited a significant correlation with those extracted from the delay epoch, suggesting an early involvement of A1 in stimulus categorization., Competing Interests: RC, SS, YB No competing interests declared, SO Reviewing editor, eLife, (© 2023, Chillale et al.) more...
- Published
- 2023
- Full Text
- View/download PDF
Catalog
3. Early selection of task-relevant features through population gating.
- Author
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Barbosa J, Proville R, Rodgers CC, DeWeese MR, Ostojic S, and Boubenec Y
- Subjects
- Rats, Animals, Acoustic Stimulation methods, Prefrontal Cortex, Brain, Auditory Cortex
- Abstract
Brains can gracefully weed out irrelevant stimuli to guide behavior. This feat is believed to rely on a progressive selection of task-relevant stimuli across the cortical hierarchy, but the specific across-area interactions enabling stimulus selection are still unclear. Here, we propose that population gating, occurring within primary auditory cortex (A1) but controlled by top-down inputs from prelimbic region of medial prefrontal cortex (mPFC), can support across-area stimulus selection. Examining single-unit activity recorded while rats performed an auditory context-dependent task, we found that A1 encoded relevant and irrelevant stimuli along a common dimension of its neural space. Yet, the relevant stimulus encoding was enhanced along an extra dimension. In turn, mPFC encoded only the stimulus relevant to the ongoing context. To identify candidate mechanisms for stimulus selection within A1, we reverse-engineered low-rank RNNs trained on a similar task. Our analyses predicted that two context-modulated neural populations gated their preferred stimulus in opposite contexts, which we confirmed in further analyses of A1. Finally, we show in a two-region RNN how population gating within A1 could be controlled by top-down inputs from PFC, enabling flexible across-area communication despite fixed inter-areal connectivity., (© 2023. The Author(s).) more...
- Published
- 2023
- Full Text
- View/download PDF
4. Distinct higher-order representations of natural sounds in human and ferret auditory cortex.
- Author
-
Landemard A, Bimbard C, Demené C, Shamma S, Norman-Haignere S, and Boubenec Y
- Subjects
- Acoustic Stimulation, Animals, Humans, Auditory Cortex physiology, Auditory Perception physiology, Ferrets physiology, Sound
- Abstract
Little is known about how neural representations of natural sounds differ across species. For example, speech and music play a unique role in human hearing, yet it is unclear how auditory representations of speech and music differ between humans and other animals. Using functional ultrasound imaging, we measured responses in ferrets to a set of natural and spectrotemporally matched synthetic sounds previously tested in humans. Ferrets showed similar lower-level frequency and modulation tuning to that observed in humans. But while humans showed substantially larger responses to natural vs. synthetic speech and music in non-primary regions, ferret responses to natural and synthetic sounds were closely matched throughout primary and non-primary auditory cortex, even when tested with ferret vocalizations. This finding reveals that auditory representations in humans and ferrets diverge sharply at late stages of cortical processing, potentially driven by higher-order processing demands in speech and music., Competing Interests: AL, CB, CD, SS, SN, YB No competing interests declared, (© 2021, Landemard et al.) more...
- Published
- 2021
- Full Text
- View/download PDF
5. Go/No-Go task engagement enhances population representation of target stimuli in primary auditory cortex.
- Author
-
Bagur S, Averseng M, Elgueda D, David S, Fritz J, Yin P, Shamma S, Boubenec Y, and Ostojic S
- Subjects
- Acoustic Stimulation, Animals, Auditory Cortex anatomy & histology, Auditory Cortex cytology, Choice Behavior physiology, Electrodes, Implanted, Female, Ferrets, Frontal Lobe anatomy & histology, Frontal Lobe cytology, Multifactor Dimensionality Reduction, Neuronal Plasticity physiology, Neurons cytology, Neurons physiology, Reinforcement, Psychology, Stereotaxic Techniques, Wakefulness physiology, Auditory Cortex physiology, Avoidance Learning physiology, Conditioning, Classical physiology, Frontal Lobe physiology, Pattern Recognition, Physiological physiology
- Abstract
Primary sensory cortices are classically considered to extract and represent stimulus features, while association and higher-order areas are thought to carry information about stimulus meaning. Here we show that this information can in fact be found in the neuronal population code of the primary auditory cortex (A1). A1 activity was recorded in awake ferrets while they either passively listened or actively discriminated stimuli in a range of Go/No-Go paradigms, with different sounds and reinforcements. Population-level dimensionality reduction techniques reveal that task engagement induces a shift in stimulus encoding from a sensory to a behaviorally driven representation that specifically enhances the target stimulus in all paradigms. This shift partly relies on task-engagement-induced changes in spontaneous activity. Altogether, we show that A1 population activity bears strong similarities to frontal cortex responses. These findings indicate that primary sensory cortices implement a crucial change in the structure of population activity to extract task-relevant information during behavior. more...
- Published
- 2018
- Full Text
- View/download PDF
6. Multi-scale mapping along the auditory hierarchy using high-resolution functional UltraSound in the awake ferret.
- Author
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Bimbard C, Demene C, Girard C, Radtke-Schuller S, Shamma S, Tanter M, and Boubenec Y
- Subjects
- Acoustic Stimulation, Animals, Auditory Cortex anatomy & histology, Auditory Cortex physiology, Auditory Pathways anatomy & histology, Auditory Pathways physiology, Brain Mapping instrumentation, Cerebrovascular Circulation physiology, Electrodes, Implanted, Female, Ferrets, Frontal Lobe anatomy & histology, Frontal Lobe physiology, Stereotaxic Techniques, Ultrasonography instrumentation, Wakefulness physiology, Auditory Cortex diagnostic imaging, Auditory Pathways diagnostic imaging, Brain Mapping methods, Frontal Lobe diagnostic imaging, Ultrasonography methods
- Abstract
A major challenge in neuroscience is to longitudinally monitor whole brain activity across multiple spatial scales in the same animal. Functional UltraSound (fUS) is an emerging technology that offers images of cerebral blood volume over large brain portions. Here we show for the first time its capability to resolve the functional organization of sensory systems at multiple scales in awake animals, both within small structures by precisely mapping and differentiating sensory responses, and between structures by elucidating the connectivity scheme of top-down projections. We demonstrate that fUS provides stable (over days), yet rapid, highly-resolved 3D tonotopic maps in the auditory pathway of awake ferrets, thus revealing its unprecedented functional resolution (100/300µm). This was performed in four different brain regions, including very small (1-2 mm
3 size), deeply situated subcortical (8 mm deep) and previously undescribed structures in the ferret. Furthermore, we used fUS to map long-distance projections from frontal cortex, a key source of sensory response modulation, to auditory cortex., Competing Interests: CB, CD, CG, SR, SS, MT, YB No competing interests declared, (© 2018, Bimbard et al.) more...- Published
- 2018
- Full Text
- View/download PDF
7. Detecting changes in dynamic and complex acoustic environments.
- Author
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Boubenec Y, Lawlor J, Górska U, Shamma S, and Englitz B
- Subjects
- Acoustic Stimulation, Electroencephalography, Humans, Models, Neurological, Psychophysics, Auditory Cortex physiology, Auditory Perception
- Abstract
Natural sounds such as wind or rain, are characterized by the statistical occurrence of their constituents. Despite their complexity, listeners readily detect changes in these contexts. We here address the neural basis of statistical decision-making using a combination of psychophysics, EEG and modelling. In a texture-based, change-detection paradigm, human performance and reaction times improved with longer pre-change exposure, consistent with improved estimation of baseline statistics. Change-locked and decision-related EEG responses were found in a centro-parietal scalp location, whose slope depended on change size, consistent with sensory evidence accumulation. The potential's amplitude scaled with the duration of pre-change exposure, suggesting a time-dependent decision threshold. Auditory cortex-related potentials showed no response to the change. A dual timescale, statistical estimation model accounted for subjects' performance. Furthermore, a decision-augmented auditory cortex model accounted for performance and reaction times, suggesting that the primary cortical representation requires little post-processing to enable change-detection in complex acoustic environments. more...
- Published
- 2017
- Full Text
- View/download PDF
8. Dynamics and maintenance of categorical responses in primary auditory cortex during task engagement.
- Author
-
Chillale, Rupesh K, Shamma, Shihab, Ostojic, Srdjan, and Boubenec, Yves
- Subjects
- *
AUDITORY cortex , *PASSIVITY (Psychology) , *COGNITIVE ability , *SPEED of sound , *FERRET - Abstract
Grouping sets of sounds into relevant categories is an important cognitive ability that enables the association of stimuli with appropriate goal-directed behavioral responses. In perceptual tasks, the primary auditory cortex (A1) assumes a prominent role by concurrently encoding both sound sensory features and task-related variables. Here, we sought to explore the role of A1 in the initiation of sound categorization, shedding light on its involvement in this cognitive process. We trained ferrets to discriminate click trains of different rates in a Go/No-Go delayed categorization task and recorded neural activity during both active behavior and passive exposure to the same sounds. Purely categorical response components were extracted and analyzed separately from sensory responses to reveal their contributions to the overall population response throughout the trials. We found that categorical activity emerged during sound presentation in the population average and was present in both active behavioral and passive states. However, upon task engagement, categorical responses to the No-Go category became suppressed in the population code, leading to an asymmetrical representation of the Go stimuli relative to the No-Go sounds and pre-stimulus baseline. The population code underwent an abrupt change at stimulus offset, with sustained responses after the Go sounds during the delay period. Notably, the categorical responses observed during the stimulus period exhibited a significant correlation with those extracted from the delay epoch, suggesting an early involvement of A1 in stimulus categorization. [ABSTRACT FROM AUTHOR] more...
- Published
- 2024
- Full Text
- View/download PDF
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