1. Rheumatoid arthritis unmasked: the power of B cell depletion therapy.
- Author
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Alghazali, Tawfeeq, Saleh, Raed Obaid, Uthirapathy, Subasini, Ballal, Suhas, Abullais, Shahabe Saquib, Kalia, Rishiv, Arya, Renu, Sharma, RSK, Kumar, Abhinav, and Abdulamer, Resan Shakir
- Abstract
Rheumatoid arthritis (RA) is an enduring autoimmune illness characterized by persistent inflammation and joint damage. Recent advancements in B cell depletion therapies (BCDTs) have provided new avenues for managing RA. This review article delves into the pathophysiology of RA, highlighting the pivotal role of B cells in disease progression. We explore the mechanisms underlying B cell depletion, focusing on monoclonal antibodies such as rituximab as well as innovative approaches like chimeric antigen receptor (CAR) T cell therapies. An in-depth analysis of clinical studies reveals the efficacy and limitations of these therapies, including success rates, side effects, and cost implications for patients. Despite promising outcomes, the incomplete depletion of B cells and associated risks underscore the need for further research. This review aims to provide a comprehensive understanding of BCDTs in RA, shed light on their potential and challenges, and guide future therapeutic strategies. [ABSTRACT FROM AUTHOR]
- Published
- 2025
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