1. Childhood Pemphigus Vulgaris during COVID-19 Outbreak Successfully Treated with Prednisone and Azathioprine: A Case Report and Literature Review.
- Author
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Vezzoli, Pamela, Parietti, Michele, Carugno, Andrea, Di Mercurio, Marco, Benaglia, Chiara, Zussino, Martina, Cavalli, Riccardo, Sena, Paolo, and Berti, Emilio
- Subjects
PEMPHIGUS vulgaris ,PEMPHIGUS ,COVID-19 pandemic ,AZATHIOPRINE ,TREATMENT effectiveness ,LITERATURE reviews - Abstract
Introduction: pemphigus vulgaris is a rare autoimmune blistering disease that involves the skin and mucous membranes and rarely occurs in pediatric age. Methods: we present a case of childhood pemphigus in a 9-year-old patient from Burkina Faso, which initially manifested with erosive lesions symmetrically distributed in the oral cavity. After a few months, we also observed hyperchromic lesions of the back. Histopathological examination of skin samples showed intraepidermal acantholysis, while direct immunofluorescence showed deposits of complement (C3) and immunoglobulins G (IgG) in the epidermidis; an ELISA test highlighted the presence of circulating autoantibodies against desmoglein 3. Results: the follow-up of this patient was made difficult by the advent of the COVID-19 outbreak. However, after about one year of combined therapy with systemic steroids and azathioprine the patient reached clinical remission. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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