1. Rituximab in systemic autoimmune rheumatic diseases: indications and practical use.
- Author
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Berghen N, Vulsteke JB, Westhovens R, Lenaerts J, and De Langhe E
- Subjects
- Antirheumatic Agents pharmacology, Autoimmune Diseases classification, Humans, Practice Guidelines as Topic, Rheumatic Diseases classification, Treatment Outcome, Autoimmune Diseases drug therapy, Rheumatic Diseases drug therapy, Rituximab pharmacology
- Abstract
Objectives: To review the therapeutic option of Rituximab, a chimeric anti-CD20 antibody, in systemic autoimmune rheumatic diseases (SARDs) such as systemic lupus erythematosus, systemic sclerosis, primary Sjögren syndrome and idiopathic inflammatory myopathy. Methods: A non-systematic review was conducted. Results: The specific role and indication of rituximab in SARDs has been the subject of multiple trials in recent years. Evidence supports the use of rituximab in moderate-to-severe refractory systemic lupus erythematosus, diffuse skin involvement in systemic sclerosis and systemic involvement in primary Sjögren syndrome. Several guidelines have adopted these indications. In addition, there is a consensus about the use of rituximab in refractory myositis. The role of rituximab in interstitial lung disease associated with these SARDs needs to be further explored. Conclusion: Rituximab is a treatment option in several SARDs. Upcoming trials, use in daily practice and the safety profile are elaborated on.
- Published
- 2019
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