1. Calprotectin: two sides of the same coin.
- Author
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Carnazzo, Valeria, Redi, Serena, Basile, Valerio, Natali, Patrizia, Gulli, Francesca, Equitani, Francesco, Marino, Mariapaola, and Basile, Umberto
- Subjects
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FECAL analysis , *AUTOIMMUNE disease diagnosis , *AUTOANTIBODIES , *BIOMARKERS , *INFLAMMATORY bowel diseases , *CHRONIC diseases , *AUTOIMMUNE diseases , *PATIENT monitoring , *NEUTROPHILS , *CALCIUM-binding proteins , *MONOCYTES - Abstract
Calprotectin (CLP) is a calcium-binding protein produced by neutrophils and monocytes in the course of inflammation. Today, the role of faecal CLP in chronic IBD is well known, but in recent years attention has shifted towards circulating CLP. In fact, this molecule can be measured in different biological fluids: blood, saliva and urine, using different analytic methods that are described in this review. Furthermore, different data confirm the relevant role of serum CLP in autoimmune diseases. In this review we will highlight the correlation between high levels of circulating CLP and specific autoantibodies of major autoimmune pathologies paving the way to the employment of CLP measurement as useful biomarker for monitoring outcome in different pathologies. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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