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Systemic lupus Erythematosus is an autoimmune disease in which organs and cells undergo damage initially mediated by tissue binding auto antibodies and immune complexes. Its presentation and course vary greatly ranging from indolent to fulminant. Here we present three cases of SLE with unusual presentations. In case 1 a 16 years old female presented with multiple swelling on the neck and loss of weight with generalized lympadenopathy. Routine investigations showed decreased haemoglobin and increased ESR. FNAC of cervical and axillary lymphnode shows reactive hyperplasia. Chest Xray showed bilateral pleural effusion, Ultrasound showed pericardial effusion and Ascites. Rheumatology work up was positive for ANA, anti RNP & anti SM. In case 2 a 13 year old girl presented with continuous low grade fever, shortness of breath, non productive cough. Chest Xray showed B/L effusion and fluid tapped was exudative, lymphocytic and was started on ATT empirically. Patient after 2 months came with dyspnea and hyperpigmented macules with scaling all over the body. Adverse drug reactions were ruled out after witholding ATT. Rheumatology work up was positive for ANA and dsDNA. In case 3 a 27 year old female presented with right sided shoulder pain, dyspnea and left cervical lymphnode enlargment. Chest Xray showed right mild pleural effusion. CT pulmonary angiogram showed thromboembolic occlusion of right lower lobe segmental pulmonary. FNAC of cervical lymphnode showed reactive hyperplasia. Connective tissue workup, was positive for APLA, anti RO/SSA. These case reports helps Pulmonologist recognise various presentations of SLE. [ABSTRACT FROM AUTHOR]