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Start Over Author "Ciani, B." Topic autonomic nervous system
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1. TLQP-21, a VGF-Derived Peptide, Increases Energy Expenditure and Prevents the Early Phase of Diet-Induced Obesity

Author

Bartolomucci, A., Corte, G. La, Possenti, R., Locatelli, V., Rigamonti, A. E., Torsello, A., Bresciani, E., Bulgarelli, I., Rizzi, R., Pavone, F., D'Amato, F. R., Severini, C., Mignogna, G., Giorgi, A., Schininà, M. E., Elia, G., Brancia, C., Ferri, G.-L., Conti, R., Ciani, B., Pascucci, T., Dell'Omo, G., Muller, E. E., Levi, A., and Moles, A.

Published
2006
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2. TLQP-21, a VGF-derived peptide, increases energy expenditure and prevents the early phase of diet-induced obesity

Author

Anna Moles, Cinzia Severini, Maria Eugenia Schininà, Alessandro Bartolomucci, Antonio Torsello, Gian-Luca Ferri, Tiziana Pascucci, I. Bulgarelli, Giacomo Dell'Omo, B. Ciani, Vittorio Locatelli, Giuseppina Mignogna, Francesca R. D'Amato, Antonello E. Rigamonti, Andrea Levi, Giuliano Elia, Elena Bresciani, Alessandra Giorgi, E. E. Müller, Roberto Rizzi, G La Corte, Roberta Possenti, Flaminia Pavone, Carla Brancia, Roberto Conti, Bartolomucci, A, La Corte, G, Possenti, R, Locatelli, V, Rigamonti, A, Torsello, A, Bresciani, E, Bulgarelli, I, Rizzi, R, Pavone, F, D'Amato, F, Severini, C, Mignogna, G, Giorgi, A, Schinina, M, Elia, G, Brancia, C, Ferri, G, Conti, R, Ciani, B, Pascucci, T, Dell'Omo, G, Muller, E, Levi, A, and Moles, A

Subjects
Blood Glucose, Leptin, Male, FOOD-INTAKE, SYMPATHETIC-NERVOUS-SYSTEM, WHITE ADIPOSE-TISSUE, Peptide Hormones, Adipose tissue, White adipose tissue, Energy homeostasis, Ion Channels, Mice, Adipose Tissue, Brown, Brown adipose tissue, peroxisome, HORMONE SECRETAGOGUE RECEPTOR, MEMBRANE-PROTEINS, GENE-EXPRESSION, MESSENGER-RNA, MICE LACKING, FAT, THERMOGENESIS, BIO/14 - FARMACOLOGIA, Uncoupling Protein 1, adrenergic receptor, peroxisome proliferator-activated receptor δ, Multidisciplinary, autonomic nervous system, beta adrenergic receptor, MALDI-TOF, neuropeptide, peroxisome proliferator-activated receptor delta, Biological Sciences, β adrenergic receptor, Thermogenin, Ghrelin, Up-Regulation, medicine.anatomical_structure, medicine.medical_specialty, proliferator activated receptor delta, Neuropeptide, Peptide hormone, Biology, Settore BIO/09, Mitochondrial Proteins, Internal medicine, Receptors, Adrenergic, beta, medicine, Animals, maldi tof, Nerve Growth Factors, Obesity, RNA, Messenger, Triglycerides, autonomic nervous system, beta adrenergic receptor, MALDI-TOF, neuropeptide, peroxisome proliferator-activated receptor delta, peroxisome proliferator-activated receptor, maldi-tof, Neuropeptides, Glucose Tolerance Test, Diet, Rats, PPAR gamma, Endocrinology, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Energy Metabolism, Peptides
Abstract

The vgf gene has been identified as an energy homeostasis regulator. Vgf encodes a 617-aa precursor protein that is processed to yield an incompletely characterized panel of neuropeptides. Until now, it was an unproved assumption that VGF-derived peptides could regulate metabolism. Here, a VGF peptide designated TLQP-21 was identified in rat brain extracts by means of immunoprecipitation, microcapillary liquid chromatography–tandem MS, and database searching algorithms. Chronic intracerebroventricular (i.c.v.) injection of TLQP-21 (15 μg/day for 14 days) increased resting energy expenditure (EE) and rectal temperature in mice. These effects were paralleled by increased epinephrine and up-regulation of brown adipose tissue β2-AR (β2 adrenergic receptor) and white adipose tissue (WAT) PPAR-δ (peroxisome proliferator-activated receptor δ), β3-AR, and UCP1 (uncoupling protein 1) mRNAs and were independent of locomotor activity and thyroid hormones. Hypothalamic gene expression of orexigenic and anorexigenic neuropeptides was unchanged. Furthermore, in mice that were fed a high-fat diet for 14 days, TLQP-21 prevented the increase in body and WAT weight as well as hormonal changes that are associated with a high-fat regimen. Biochemical and molecular analyses suggest that TLQP-21 exerts its effects by stimulating autonomic activation of adrenal medulla and adipose tissues. In conclusion, we present here the identification in the CNS of a previously uncharacterized VGF-derived peptide and prove that its chronic i.c.v. infusion effected an increase in EE and limited the early phase of diet-induced obesity.

Published
2006
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