1. ZIF-Based Nanoparticles Combine X-Ray-Induced Nitrosative Stress with Autophagy Management for Hypoxic Prostate Cancer Therapy.
- Author
-
Li Y, Gong T, Gao H, Chen Y, Li H, Zhao P, Jiang Y, Wang K, Wu Y, Zheng X, and Bu W
- Subjects
- Antineoplastic Agents chemistry, Cell Survival drug effects, Drug Screening Assays, Antitumor, Humans, Imidazoles chemistry, Male, Metal-Organic Frameworks chemistry, Nitrosative Stress drug effects, Prostatic Neoplasms metabolism, Prostatic Neoplasms pathology, X-Rays, Zeolites chemistry, Antineoplastic Agents pharmacology, Autophagy drug effects, Imidazoles pharmacology, Metal-Organic Frameworks pharmacology, Nanoparticles chemistry, Prostatic Neoplasms drug therapy, Zeolites pharmacology
- Abstract
Although reactive oxygen species (ROS)-mediated tumor treatments are predominant in clinical applications, ROS-induced protective autophagy promotes cell survival, especially in hypoxic tumors. Herein, X-ray triggered nitrite (NO
2 ) is used for hypoxic prostate cancer therapy by inhibiting autophagy and inducing nitrosative stress based on an electrophilic zeolitic imidazole framework (ZIF-82-PVP). After internalization of pH-responsive ZIF-82-PVP nanoparticles, electrophilic ligands and Zn- ) is used for hypoxic prostate cancer therapy by inhibiting autophagy and inducing nitrosative stress based on an electrophilic zeolitic imidazole framework (ZIF-82-PVP). After internalization of pH-responsive ZIF-82-PVP nanoparticles, electrophilic ligands and Zn2+ , which inhibits autophagy and further elevates lethal nitrosative stress levels. In addition, dissociated Zn2 - , which inhibits autophagy and further elevates lethal nitrosative stress levels. In addition, dissociated Zn2+ specifically limits the migration and invasion of prostate cancer cells through ion interference. In vitro and in vivo results indicate that ZIF-82-PVP nanoparticles under X-ray irradiation can effectively promote the apoptosis of hypoxic prostate cancer cells. Overall, this nitrosative stress-mediated tumor therapy strategy provides a novel approach targeting hypoxic tumors., (© 2021 Wiley-VCH GmbH.)- Published
- 2021
- Full Text
- View/download PDF