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Land–atmosphere coupling (LAC) plays a significant role in weather and climate and is related to droughts and heatwaves. We propose a simple and efficient LAC diagnosis method based on the analysis of water isotopes in atmospheric water vapour and precipitation. Using the method, we identify the primary LAC hotspot regions of the globe and reveal the seasonality of LAC strength. We find that LAC strength exhibits a relationship with latitude. Low latitudes present stronger LAC strength and contribute more significantly to the overall LAC area compared to boreal middle and high latitudes. It's important to note that LAC primarily manifests in the troposphere and is detected in the lower stratosphere of low latitudes, with limited influence observed in the stratosphere. However, the impact of LAC is noticeable in the upper stratosphere in boreal middle and high latitudes. Moreover, the seasonality of LAC strength is pronounced. On a global scale, the season with the strongest LAC is boreal autumn in the Northern Hemisphere but boreal summer in the Southern Hemisphere. Notably, this pattern does not exhibit a seesaw effect between the two hemispheres. Our isotope-based LAC diagnosis method captures the major LAC hotspots found in previous work and validates the seasonality of LAC within these hotspots. This substantiates the reliability and effectiveness of our isotope-based approach. [ABSTRACT FROM AUTHOR]