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Innovation in cold-formed steel framing systems is needed for opening flexibility and application in mid-rise buildings. Hence, this study proposes a closed built-up section using four cold-formed steel (CFS) open sections with a high load bearing capacity that potentially enables the development of high-performance cold-formed steel framing systems for these. The closed section by combining four open CFS sections using fasteners can effectively enhance the load capacity of the sections under axial loading. With a specially designed intersections gusset plate this built-up section offers more potential configurations of beam-column moment connections for CFS structures. First, a heuristic optimization was performed to identify a high-performance section based on the local and distortional buckling strengths using the finite strip method. Second, a test program was developed to investigate the load bearing capacity and failure behaviors of the optimized built-up closed section under axial and eccentric loading. Third, their load bearing capacities were compared with several other closed sections such as the rectangular hollow tube (RHS) of equal cross-sectional area or equal moment of inertia to highlight the high material efficiency. This study paved the groundwork for exploring high-performance cold-formed steel framing systems with this unique closed built-up section. • Proposed a closed built-up section for two-way cold-formed steel framing systems. • Investigated the compression behavior and strength of specimens under axial and eccentric loadings. • Achieved a high load-bearing capacity of the closed built-up section. • Conducted a comparable analysis with equivalent rectangular hollow tube sections numerically. [ABSTRACT FROM AUTHOR]