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Your search keyword '"Ahmed, Zubair"' showing total 1 results
Start Over Author "Ahmed, Zubair" Topic axons Topic checkpoint kinase 2
1 results on '"Ahmed, Zubair"'

1. Inhibition of Chk2 promotes neuroprotection, axon regeneration, and functional recovery after CNS injury.

Author

Taylor, Matthew J., Thompson, Adam M., Alhajlah, Sharif, Tuxworth, Richard I., and Ahmed, Zubair

Subjects
*AXONS, *RETINAL ganglion cells, *CHECKPOINT kinase 2, *CENTRAL nervous system injuries, *PIGMENT epithelium-derived factor, *CHECKPOINT kinase 1, *MEDICAL sciences
Abstract

The article discusses a study which showed that targeting of the central ataxia telangiectasia-mutated-checkpoint kinase-2 (ATM-Chk2) pathway regulating the response to double-strand breaks slows neural decline in Drosophila models of chronic neurodegeneration. Results show that Chk2 inhibitor, prexasertib, represents a treatment option to promote functional recovery after spinal cord or optic nerve injury. Also cited are the neuroprotective effects of prexasertib and the experimental design.

Published
2022
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