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Start Over Author "Molina Torres, Carmen Amelia" Topic azithromycin
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1. Evaluation of the intracellular activity of drugs against Mycobacterium abscessus using a THP-1 macrophage model.

Author

Molina-Torres, Carmen Amelia, Tamez-Peña, Lorena, Castro-Garza, Jorge, Ocampo-Candiani, Jorge, and Vera-Cabrera, Lucio

Subjects
*COLONY-forming units assay, *MYCOBACTERIUM, *MYCOBACTERIA, *MACROPHAGES, *CLARITHROMYCIN, *AZITHROMYCIN
Abstract

We evaluated the antimicrobial effectiveness against M. abscessus in a THP-1 cell line model. No intracellular activity was observed when using amikacin or imipenem. A bacteriostatic effect was observed for cefoxitin, clarithromycin and azithromycin. Tigecycline showed the best antibacterial effect by decreasing the intracellular growth up to bactericidal level. [ABSTRACT FROM AUTHOR]

Published
2018
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