1. Decreased B Cells on Admission Associated With Prolonged Viral RNA Shedding From the Respiratory Tract in Coronavirus Disease 2019: A Case-Control Study.
- Author
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Hao, Shaorui, Lian, Jiangshan, Lu, Yingfeng, Jia, Hongyu, Hu, Jianhua, Yu, Guodong, Wang, Xiaoyan, Xu, Kaijin, Ni, Qin, Li, Yongtao, Liu, Jun, Zhao, Hong, Zhang, Xuan, Yu, Liang, Yu, Xiaopeng, Xiang, Dairong, Chen, Yu, Zheng, Shufa, Qiu, Yunqing, and Li, Lanjuan
- Subjects
COVID-19 ,VIRAL shedding ,RESPIRATORY diseases ,B cells ,CASE-control method ,RNA metabolism ,RESPIRATORY organs ,VIRAL pneumonia ,VIRAL physiology ,CYTOKINES ,RESEARCH ,TIME ,RESEARCH methodology ,CORONAVIRUS diseases ,RNA ,RETROSPECTIVE studies ,EVALUATION research ,COMPARATIVE studies ,EPIDEMICS ,MENTAL health surveys ,LOGISTIC regression analysis ,POLYMERASE chain reaction ,LYMPHOCYTE count ,PROPORTIONAL hazards models - Abstract
The viral RNA shedding time (VST) for severe acute respiratory syndrome coronavirus 2 has not been well characterized. Clinical data were collected and compared between patients with short and long VSTs (in the lower and upper quartiles, respectively). The probability of recurrent positive reverse-transcription polymerase chain reaction results decreased sharply to 4.8% after 3 consecutive negative results. A series of ≥3 consecutive negative results was suitable as a criterion for the end of viral RNA shedding. The VST for shedding from the respiratory tract was significantly shorter in patients with normal B-cell counts on admission than in those with decreased B-cell counts (median [interquartile range], 11 [9-13] vs 16 [12-20] days, respectively; P = .001). [ABSTRACT FROM AUTHOR]
- Published
- 2020
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