1. B cell infiltration is associated with the increased IL-17 and IL-22 expression in the lungs of patients with tuberculosis
- Author
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Zhang, Mingxia, Wang, Zheng, Graner, Michael W., Yang, Lin, Liao, Mingfeng, Yang, Qianting, Gou, Jizhou, Zhu, Yuzhen, Wu, Chi, Liu, Haiying, Zhou, Boping, and Chen, Xinchun
- Subjects
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TUBERCULOSIS , *B cells , *INTERLEUKINS , *MYCOBACTERIUM tuberculosis , *LUNG diseases , *CELL aggregation , *GENE expression , *CELLULAR control mechanisms - Abstract
Abstract: Although it has been recognized that ectopic follicle-like B cell aggregate formation is common in the lungs of patients with tuberculosis, the role of infiltrated B cells in human tuberculosis remains to be elucidated. In the present study, we showed that ectopic B cell aggregate formation was associated with containment of Mycobacterium tuberculosis. The area ratio of ectopic B cell aggregates was correlated with localized IL-17 mRNA expression and peripheral TGF-β and IL-6 mRNA expression. Depletion of B cells from pleural fluid mononuclear cells resulted in significantly diminished M. tuberculosis antigen-specific IL-17 and IL-22 production, but not in IFN-γ secretion. Therefore, ectopic lung B cell formation is important for containment of M. tuberculosis, and up-regulation of IL-17 and IL-22 responses may be an important mechanism underlying the protective role B cells in human tuberculosis. [Copyright &y& Elsevier]
- Published
- 2011
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