1. Beyond the antibody: B cells as a target for bacterial infection.
- Author
-
García-Gil A, Lopez-Bailon LU, and Ortiz-Navarrete V
- Subjects
- Animals, Antibodies, Bacterial biosynthesis, Apoptosis immunology, B-Lymphocytes microbiology, Bacterial Infections immunology, Bacterial Infections pathology, Cytokines biosynthesis, Cytokines immunology, Gram-Negative Bacteria growth & development, Gram-Negative Bacteria pathogenicity, Gram-Positive Bacteria growth & development, Gram-Positive Bacteria pathogenicity, Humans, Inflammasomes immunology, Microbial Viability immunology, Pinocytosis immunology, B-Lymphocytes immunology, Bacterial Infections microbiology, Gram-Negative Bacteria immunology, Gram-Positive Bacteria immunology, Immune Evasion
- Abstract
It is well established that B cells play an important role during infections beyond antibody production. B cells produce cytokines and are APCs for T cells. Recently, it has become clear that several pathogenic bacterial genera, such as Salmonella, Brucella, Mycobacterium, Listeria, Francisella, Moraxella, and Helicobacter, have evolved mechanisms such as micropinocytosis induction, inflammasome down-regulation, inhibitory molecule expression, apoptosis induction, and anti-inflammatory cytokine secretion to manipulate B cell functions influencing immune responses. In this review, we summarize our current understanding of B cells as targets of bacterial infection and the mechanisms by which B cells become a niche for bacterial survival and replication away from extracellular immune responses such as complement and antibodies., (©2019 Society for Leukocyte Biology.)
- Published
- 2019
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