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1. Generation of Novel Severe Acute Respiratory Syndrome Coronavirus 2 Variants on the B.1.1.7 Lineage in 3 Patients With Advanced Human Immunodeficiency Virus-1 Disease.

Author

Riddell, Anna C, Kele, Beatrix, Harris, Kathryn, Bible, Jon, Murphy, Maurice, Dakshina, Subathira, Storey, Nathaniel, Owoyemi, Dola, Pade, Corinna, Gibbons, Joseph M, Harrington, David, Alexander, Eliza, McKnight, Áine, and Cutino-Moguel, Teresa

Subjects
HIV infections, HIV-positive persons, IN vitro studies, SARS-CoV-2, COVID-19, GENETIC mutation, IN vivo studies, IMMUNOCOMPROMISED patients, RISK assessment, CASE studies
Abstract

The emergence of new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants is of public health concern in case of vaccine escape. Described are 3 patients with advanced human immunodeficiency virus (HIV)-1 and chronic SARS-CoV-2 infection in whom there is evidence of selection and persistence of novel mutations that are associated with increased transmissibility and immune escape. [ABSTRACT FROM AUTHOR]

Published
2022
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