1. VISTA expression on tumor-infiltrating inflammatory cells in primary cutaneous melanoma correlates with poor disease-specific survival.
- Author
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Kuklinski LF, Yan S, Li Z, Fisher JL, Cheng C, Noelle RJ, Angeles CV, Turk MJ, and Ernstoff MS
- Subjects
- B7 Antigens immunology, B7-H1 Antigen immunology, Female, Follow-Up Studies, Humans, Lymphocytes, Tumor-Infiltrating metabolism, Male, Melanoma immunology, Melanoma metabolism, Melanoma pathology, Middle Aged, Prognosis, Programmed Cell Death 1 Receptor immunology, Skin Neoplasms immunology, Skin Neoplasms metabolism, Skin Neoplasms pathology, Survival Rate, Tumor Microenvironment, Melanoma, Cutaneous Malignant, B7 Antigens metabolism, B7-H1 Antigen metabolism, Biomarkers, Tumor metabolism, Lymphocytes, Tumor-Infiltrating immunology, Melanoma mortality, Programmed Cell Death 1 Receptor metabolism, Skin Neoplasms mortality
- Abstract
Adaptive immune responses contribute to the pathogenesis of melanoma by facilitating immune evasion. V-domain Ig suppressor of T-cell activation (VISTA) is a potent negative regulator of T-cell function and is expressed at high levels on monocytes, granulocytes, and macrophages, and at lower densities on T-cell populations within the tumor microenvironment. In this study, 85 primary melanoma specimens were selected from pathology tissue archives and immunohistochemically stained for CD3, PD-1, PD-L1, and VISTA. Pearson's correlation coefficients identified associations in expression between VISTA and myeloid infiltrate (r = 0.28, p = 0.009) and the density of PD-1+ inflammatory cells (r = 0.31, p = 0.005). The presence of VISTA was associated with a significantly worse disease-specific survival in univariate analysis (hazard ratio = 3.57, p = 0.005) and multivariate analysis (hazard ratio = 3.02, p = 0.02). Our findings show that VISTA expression is an independent negative prognostic factor in primary cutaneous melanoma and suggests its potential as an adjuvant immunotherapeutic intervention in the future. more...
- Published
- 2018
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