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Highlights • A new compartmental model for the co-dynamics of measles and dysentery diarrhea is proposed. • The system exhibits a backward bifurcation. • Optimal control and cost-effectiveness analysis are addressed. • Numerical simulations illustrate theoretical results and indicate suggestions for disease elimination. • The most cost-effective strategy for the control of the diseases is recommended. Abstract In this paper we propose a co-dynamics deterministic system for measles and dysentery diarrhea diseases in a single host population. Using center manifold theory, we show that the co-dynamics model may exhibit a backward bifurcation for some parameter values. Numerical simulations of the system show that the two diseases always coexist if R 0 > 1. The system is extended to include time-dependent control-variables: vaccination, treatment and sanitation of the environment, to minimize the number of infected humans and the cost of implementation of the controls. The Pontryagin Maximum Principle was employed to find the necessary conditions for the existence of the optimal controls. The numerical simulations show that the effective controls could reduce the diseases in the community. The incremental cost-effectiveness ratio was used to quantify the cost-effectiveness analysis. It is found that the control strategy which implements vaccination, treatment of dysentery diarrhea and sanitation of the environment is the most cost-effective. [ABSTRACT FROM AUTHOR]

Measles is an awfully contagious acute viral infection. It can be fatal, causing cough, red eyes, followed by a fever and skin rash with signs of respiratory infection. In this paper, we propose and analyze a model describing the transmission dynamics of a measles epidemic in the human population using the stability theory of differential equations. The model proposed undergoes a backward bifurcation for some parameter values. Sensitivity analysis is carried out on the model parameters in order to determine their impact on the disease dynamics. We extend the model to an optimal control problem by including time-dependent control variables: prevention, treatment of infected people and vaccination of the susceptible humans. In an attempt to minimize the infected people and the cost applied we design the cost functional. Next, we show that optimal control exists for the system, and the Pontryagin maximum principle is employed to characterize the continuous controls. Numerical simulation is performed to justify the analytical results and discussed quantitatively. [ABSTRACT FROM AUTHOR]