1. 8-Oxoadenine: A «New» Player of the Oxidative Stress in Mammals?
- Author
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Kruchinin, Alexander A., Kamzeeva, Polina N., Zharkov, Dmitry O., Aralov, Andrey V., and Makarova, Alena V.
- Subjects
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DNA ligases , *OXIDATIVE stress , *EUKARYOTIC cells , *DNA polymerases , *CELL physiology , *BACTERIAL cells , *GENETIC toxicology - Abstract
Numerous studies have shown that oxidative modifications of guanine (7,8-dihydro-8-oxoguanine, 8-oxoG) can affect cellular functions. 7,8-Dihydro-8-oxoadenine (8-oxoA) is another abundant paradigmatic ambiguous nucleobase but findings reported on the mutagenicity of 8-oxoA in bacterial and eukaryotic cells are incomplete and contradictory. Although several genotoxic studies have demonstrated the mutagenic potential of 8-oxoA in eukaryotic cells, very little biochemical and bioinformatics data about the mechanism of 8-oxoA-induced mutagenesis are available. In this review, we discuss dual coding properties of 8-oxoA, summarize historical and recent genotoxicity and biochemical studies, and address the main protective cellular mechanisms of response to 8-oxoA. We also discuss the available structural data for 8-oxoA bypass by different DNA polymerases as well as the mechanisms of 8-oxoA recognition by DNA repair enzymes. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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