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Start Over Author "Geurts Y" Topic bacterial proteins
4 results on '"Geurts Y"'

1. Novel Carbapenemases FLC-1 and IMI-2 Encoded by an Enterobacter cloacae Complex Isolated from Food Products.

Author

Brouwer MSM, Tehrani KHME, Rapallini M, Geurts Y, Kant A, Harders F, Mashayekhi V, Martin NI, Bossers A, Mevius DJ, Wit B, and Veldman KT

Subjects
Anti-Bacterial Agents pharmacology, Bacterial Proteins genetics, Cephalosporins metabolism, Enterobacter drug effects, Enterobacter cloacae drug effects, Microbial Sensitivity Tests, Plasmids genetics, beta-Lactamases genetics, Bacterial Proteins metabolism, Enterobacter cloacae enzymology, beta-Lactamases metabolism
Abstract

Food for human consumption is screened widely for the presence of antibiotic-resistant bacteria to assess the potential for transfer of resistant bacteria to the general population. Here, we describe an Enterobacter cloacae complex isolated from imported seafood that encodes two carbapenemases on two distinct plasmids. Both enzymes belong to Ambler class A β-lactamases, the previously described IMI-2 and a novel family designated FLC-1. The hydrolytic activity of the novel enzyme against aminopenicillins, cephalosporins, and carbapenems was determined., (Copyright © 2019 Brouwer et al.)

Published
2019
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2. Enterobacter cloacae Complex Isolated from Shrimps from Vietnam Carrying bla IMI-1 Resistant to Carbapenems but Not Cephalosporins.

Author

Brouwer MSM, Rapallini M, Geurts Y, Harders F, Bossers A, Mevius DJ, Wit B, and Veldman KT

Subjects
Animals, Carbapenem-Resistant Enterobacteriaceae drug effects, Carbapenem-Resistant Enterobacteriaceae isolation & purification, Enterobacter cloacae genetics, Enterobacter cloacae isolation & purification, Fisheries, Interspersed Repetitive Sequences genetics, Microbial Sensitivity Tests, Vietnam, Anti-Bacterial Agents pharmacology, Bacterial Proteins genetics, Carbapenem-Resistant Enterobacteriaceae genetics, Carbapenems pharmacology, Cephalosporins pharmacology, Enterobacter cloacae drug effects, Penaeidae microbiology, Shellfish microbiology, beta-Lactamases genetics
Published
2018
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3. ESBL/AmpC-producing Enterobacteriaceae in households with children of preschool age: prevalence, risk factors and co-carriage.

Author

van den Bunt G, Liakopoulos A, Mevius DJ, Geurts Y, Fluit AC, Bonten MJ, Mughini-Gras L, and van Pelt W

Subjects
Adult, Bacterial Proteins biosynthesis, Child, Preschool, Enterobacteriaceae genetics, Enterobacteriaceae isolation & purification, Enterobacteriaceae metabolism, Enterobacteriaceae Infections microbiology, Enterobacteriaceae Infections transmission, Feces microbiology, Female, Humans, Infant, Male, Meat microbiology, Microbial Sensitivity Tests, Netherlands epidemiology, Prevalence, Risk Factors, Surveys and Questionnaires, beta-Lactamases biosynthesis, Anti-Bacterial Agents therapeutic use, Bacterial Proteins genetics, Enterobacteriaceae drug effects, Enterobacteriaceae Infections drug therapy, Enterobacteriaceae Infections epidemiology, beta-Lactamases genetics
Abstract

Objectives: ESBL/AmpC-producing Enterobacteriaceae are an emerging public health concern. As households with preschool children may substantially contribute to the community burden of antimicrobial resistance, we determined the prevalence, risk factors and co-carriage of ESBL/AmpC-producing bacteria in preschool children and their parents., Methods: From April 2013 to January 2015, each month 2000 preschool children were randomly selected from Dutch population registries. The parents were invited to complete an epidemiological questionnaire and to obtain and send a faecal sample from the selected child and from one parent. Samples were tested for ESBL/AmpC-producing bacteria. Logistic regression was used to identify risk factors for ESBL/AmpC carriage in children and parents, and findings were internally validated by bootstrapping., Results: In total, 1016 families were included and ESBL/AmpC prevalence was 4.0% (95% CI 3.2%-5.0%); 3.5% (95% CI 2.5%-4.8%) in children and 4.5% (95% CI 3.4%-6.0%) in parents. Attending a daycare centre (DCC) was the only significant risk factor for children (OR 2.1, 95% CI 1.0-4.3). For parents, the only significant risk factor was having one or more children attending DCCs (OR 2.2, 95% CI 1.2-4.8). For parents of ESBL/AmpC-positive children the OR for ESBL/AmpC carriage was 19.7 (95% CI 9.2-42.4). Co-carriage of specific ESBL/AmpC genotypes in child and parent occurred more often than expected by chance (14.6% versus 1.1%, P < 0.001)., Conclusions: In this study, intestinal carriage with ESBL/AmpCs was detected in ∼4% of households with preschool children. DCC attendance was a risk factor in both children and parents and co-carriage of specific genotypes frequently occurred in child-parent pairs. These findings suggest household transmission or/and family-specific exposure to common sources of ESBL/AmpC-producing bacteria., (© The Author 2016. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.)

Published
2017
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4. ESBL/AmpC-producing Enterobacteriaceae in households with children of preschool age : prevalence, risk factors and co-carriage

Author

Bunt, G., Liakopoulos, Apostolos, Mevius, D J, Geurts, Y, Fluit, Ad C, Bonten, Marc J M, Mughini-Gras, L, van Pelt, W, dI&I I&I-4, LS Klinisch Onderzoek Wagenaar, dIRAS RA-I&I I&I, dI&I I&I-4, LS Klinisch Onderzoek Wagenaar, and dIRAS RA-I&I I&I

Subjects
0301 basic medicine, Male, Pediatrics, Epidemiology, preschool child, Feces, 0302 clinical medicine, Risk Factors, Surveys and Questionnaires, Antimicrobial chemotherapy, Prevalence, polycyclic compounds, Medicine, Pharmacology (medical), 030212 general & internal medicine, bacteria, Netherlands, Preschool child, disease transmission, child, Enterobacteriaceae Infections, stool specimen, Anti-Bacterial Agents, Infectious Diseases, Child, Preschool, Female, Disease transmission, Microbiology (medical), Adult, medicine.medical_specialty, Meat, Bioinformatica & Diermodellen, 030106 microbiology, Microbial Sensitivity Tests, Stool specimen, beta-Lactamases, Bacterial protein, 03 medical and health sciences, Bacterial Proteins, Environmental health, Bio-informatics & Animal models, Journal Article, Life Science, Humans, Epidemiology, Bio-informatics & Animal models, extended-spectrum beta lactamases, Epidemiologie, Pharmacology, business.industry, Infant, biochemical phenomena, metabolism, and nutrition, bacterial infections and mycoses, parent, Carriage, Epidemiologie, Bioinformatica & Diermodellen, business, enterobacteriaceae
Abstract

OBJECTIVES: ESBL/AmpC-producing Enterobacteriaceae are an emerging public health concern. As households with preschool children may substantially contribute to the community burden of antimicrobial resistance, we determined the prevalence, risk factors and co-carriage of ESBL/AmpC-producing bacteria in preschool children and their parents. METHODS: From April 2013 to January 2015, each month 2000 preschool children were randomly selected from Dutch population registries. The parents were invited to complete an epidemiological questionnaire and to obtain and send a faecal sample from the selected child and from one parent. Samples were tested for ESBL/AmpC-producing bacteria. Logistic regression was used to identify risk factors for ESBL/AmpC carriage in children and parents, and findings were internally validated by bootstrapping. RESULTS: In total, 1016 families were included and ESBL/AmpC prevalence was 4.0% (95% CI 3.2%-5.0%); 3.5% (95% CI 2.5%-4.8%) in children and 4.5% (95% CI 3.4%-6.0%) in parents. Attending a daycare centre (DCC) was the only significant risk factor for children (OR 2.1, 95% CI 1.0-4.3). For parents, the only significant risk factor was having one or more children attending DCCs (OR 2.2, 95% CI 1.2-4.8). For parents of ESBL/AmpC-positive children the OR for ESBL/AmpC carriage was 19.7 (95% CI 9.2-42.4). Co-carriage of specific ESBL/AmpC genotypes in child and parent occurred more often than expected by chance (14.6% versus 1.1%, P

Published
2017

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