1. Epigallocatechin-3-gallate inhibits bacterial virulence and invasion of host cells.
- Author
-
Tsou LK, Yount JS, and Hang HC
- Subjects
- Catechin chemistry, Catechin isolation & purification, Catechin pharmacology, Dose-Response Relationship, Drug, Epithelial Cells microbiology, HeLa Cells, Humans, Microbial Sensitivity Tests, Molecular Structure, Plant Extracts chemistry, Plant Extracts isolation & purification, Structure-Activity Relationship, Tea chemistry, Bacterial Proteins antagonists & inhibitors, Catechin analogs & derivatives, Epithelial Cells drug effects, Plant Extracts pharmacology, Salmonella typhimurium drug effects
- Abstract
Increasing antibiotic resistance and beneficial effects of host microbiota has motivated the search for anti-infective agents that attenuate bacterial virulence rather than growth. For example, we discovered that specific flavonoids such as baicalein and quercetin from traditional medicinal plant extracts could attenuate Salmonella enterica serovar Typhimurium type III protein secretion and invasion of host cells. Here, we show epigallocatechin-3-gallate from green tea extracts also inhibits the activity of S. Typhimurium type III protein effectors and significantly reduces bacterial invasion into host cells. These results reveal additional dietary plant metabolites that can attenuate bacterial virulence and infection of host cells., (Copyright © 2017. Published by Elsevier Ltd.)
- Published
- 2017
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