1. A zebrafish homologue of the murineHox-2.1 gene
- Author
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Anders Molven, Anders Fjose, and Pål R. Njølstad
- Subjects
animal structures ,Transcription, Genetic ,Protein homology ,Molecular Sequence Data ,EMX2 ,Cyprinidae ,DNA, Recombinant ,Biophysics ,Homeobox A1 ,Biology ,Biochemistry ,NKX2-3 ,Homeobox protein Nkx-2.5 ,Mice ,Structural Biology ,Sequence Homology, Nucleic Acid ,Genetics ,Animals ,Homeobox ,Amino Acid Sequence ,CDX2 ,Molecular Biology ,Zebrafish ,Base Sequence ,(Brachydanio rerio) ,DLX3 ,Genes, Homeobox ,Nucleic Acid Hybridization ,DNA ,Cell Biology ,HNF1B ,Bacteriophage lambda ,Molecular biology ,Drosophila melanogaster ,Gene Expression Regulation ,Embryogenesis ,embryonic structures - Abstract
Homeobox-containing sequences were isolated from a genomic library of zebrafish (Brachydanio rerio). A λ clone containing two homeobox cross-hybridizing regions was characterized. DNA sequencing of one of these regions (ZF-21) revealed that it contains a homeobox closely related to the Antennapedia class of Drosophila homeobox sequences. Moreover, the deduced amino acid sequence of the C-terminal end (81 residues including the homeobox) is identical to the corresponding part of the murine Hox-2.1 protein. Similar to Hox-2.1, a ZF-21 derived transcript of 2.3 kb is present in embryos at the somite forming stages.
- Published
- 1988
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