1. Synthesis of Novel bis-Spirooxindoles Using Triethylamine as a Homogeneous Base Catalyst under Mild Conditions.
- Author
-
Mohammadi, Somaye and Naeimi, Hossein
- Subjects
- *
BASE catalysts , *TRIETHYLAMINE , *MELTING points , *INDOLE compounds , *BIOCOMPLEXITY - Abstract
(6R)-1-((3S)-3'-Amino-6-chloro-2',2'-dicyano-2-oxo-7'-propyl-6',7',8',8a'-tetrahydro-2'h-spir... 0.73 g, 88% yield, 35 min, white solid; m.p.: 237-239 °C, IR (KBr): v = 3663, 3553, 3372, 3216, 2908, 2856, 2216, 1743, 1662, 1589, 1475, 1431, 1289, 1184, 1098, 1015, 832, 651, 606 cm SP -1 sp ; SP 1 sp H NMR (400 MHz, DMSO-d6) 10.84 (s, 2H, NH,NH), 8.34 (s, 1H, NH), 7.87 (s, 2H, CH, NH), 7.28 (s, 2H, NH2), 6.76-7.14 (m, 6H), 5.77 (s, 1H), 4.12 (s, 1H), 2.50 (s, 3H), 1.50 (s, 6H), 1.05-1.18 (d, J = 53.6 Hz, 9H), 0.79 (s, 6H), 0.16 (s, 2H); SP 13 sp C{ SP 1 sp H} NMR (100 MHz, DMSO I d i SB 6 sb ) 173.9, 173.70, 158.4, 156.8, 156.8, 148.8, 147.1, 141.2, 131.0, 129.5, 129.1, 127.0, 126.7, 126.2, 126.0, 125.9, 125.75, 122.7, 121.3, 120.7, 116.8, 116.6, 115.6, 114.8, 110.9, 110.6, 81.3, 80.6, 54.8, 53.8, 52.85, 39.8, 39.6, 38.6, 38.4, 38.1, 38.1, 37.4, 29.8, 19.2, 14.0; MS (EI), m/z (%) = 835 ([M] SP + sp , 0.8), 834 (1.5), 444 (24), 412 (67),392 (26), 323 (36), 308 (38), 187 (50), 166 (64), 114 (45), 77 (30), 58 (60), 41 (100). [Extracted from the article]
- Published
- 2021
- Full Text
- View/download PDF