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Intense physical activity can induce metabolic changes that modify specific biochemical biomarkers. In this scenario, the purpose of our study was to evaluate how intense physical activity can affect oxidative metabolism. Following this, fifteen professional basketball players and fifteen sedentary controls were recruited and subjected to two samplings of serum and urine in the pre-season (September) and two months after the start of the competitive season (November). Our results have shown an increase in athletes compared to controls in CK and LDH in September (respectively, p -value 0.003 and p -value < 0.001) and in November (both p -value < 0.001), whereas ALT is increased only in November ( p -value 0.09). GGT serum levels were decreased in athletes compared to controls in both months (in September p -value 0.001 and in November p -value < 0.001). A gene expression analysis, carried out using RT-PCR , has revealed that IL-2 , IL-6 , IL-8 , xCT and GCLM are increased in athletes in both months ( p -value < 0.0001), while IL-10 and CHAC1 are increased only in September if compared to the controls (respectively, p -value 0.040 and p -value < 0.001). In conclusion, physical activity creates an adaptation of the systems involved in oxidative metabolism but without causing damage to the liver or kidney. This information could be of help to sports doctors for the prevention of injuries and illnesses in professional athletes for the construction of the athlete's passport.