1. Recommendations for Comparison of Productivity Between Fed-Batch and Perfusion Processes.
- Author
-
Bausch M, Schultheiss C, and Sieck JB
- Subjects
- Animals, Antibodies, Monoclonal biosynthesis, Antibodies, Monoclonal chemistry, Batch Cell Culture Techniques economics, Biopharmaceutics economics, Bioreactors economics, CHO Cells, Cell Count, Cricetulus, Culture Media, Models, Theoretical, Batch Cell Culture Techniques methods, Batch Cell Culture Techniques standards, Biopharmaceutics standards, Bioreactors standards
- Abstract
Due to the growing interest in integrated continuous processing in the biopharmaceutical industry, productivity comparison of batch-based and continuous processes is considered a challenge. Integrated continuous manufacturing of biopharmaceuticals requires scientists and engineers to collaborate effectively. Differing definitions, for example, of volumetric productivity, may cause confusion in this interdisciplinary field. Therefore, the aim of this communication is to reiterate the standard definitions and their underlying assumptions. Applying them to an exemplary model scenario allows to demonstrate the differences and to develop recommendations for the comparison of productivity of different upstream processes., (© 2018 The Authors. Biotechnology Journal Published by Wiley-VCHVerlag GmbH & Co. KGaA, Weinheim.)
- Published
- 2019
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