1. Secretion of interleukin-17 by CD8+ T cells expressing CD146 (MCAM).
- Author
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Dagur PK, Biancotto A, Stansky E, Sen HN, Nussenblatt RB, and McCoy JP
- Subjects
- Birdshot Chorioretinopathy, CD146 Antigen immunology, CD4-Positive T-Lymphocytes immunology, CD4-Positive T-Lymphocytes metabolism, CD8-Positive T-Lymphocytes metabolism, Female, Humans, Interleukin-17 biosynthesis, Interleukin-17 immunology, Lymphocyte Activation immunology, Male, Behcet Syndrome immunology, CD8-Positive T-Lymphocytes immunology, Chorioretinitis immunology, Interleukin-17 metabolism, Sarcoidosis immunology
- Abstract
Interleukin-17 (IL-17) has been associated with the pathogenesis of numerous autoimmune diseases. CD4+ T cells secreting IL-17 are termed Th17 cells. CD8+ T cells, designated Tc17 cells, are also capable of secreting IL-17. Here we describe a population of Tc17 cells characterized by the expression of surface CD146, an endothelial adhesion molecule. These cells display signatures of a human Tc17 genotype and phenotype. Circulating CD8+CD146+ T cells are present in low levels in healthy adults. Elevations in CD8+CD146+ T cells are found in Behcet's disease and birdshot retinochoroidopathy, which have been reported to have HLA class I associations. Sarcoidosis does not have a class I association and displays an increase in CD4+ CD146+ T cells but not in CD8+CD146+ T cells. CD146 on these cells may facilitate their ability to bind to, and migrate through, endothelium, as has been reported for CD4+CD146+ T cells., (Published by Elsevier Inc.)
- Published
- 2014
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