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Start Over Author "Yang Yao, Daniele" Topic behcet syndrome
2 results on '"Yang Yao, Daniele"'

1. Tracing Behçet's disease origins along the Silk Road: an anthropological evolutionary genetics perspective.

Author

Sazzini M, Garagnani P, Sarno S, De Fanti S, Lazzano T, Yang Yao D, Boattini A, Pazzola G, Maramotti S, Boiardi L, Franceschi C, Salvarani C, and Luiselli D

Subjects
Asia ethnology, Behcet Syndrome diagnosis, Behcet Syndrome epidemiology, Cluster Analysis, Genetic Predisposition to Disease, Genetics, Population, Haplotypes, Humans, Italy epidemiology, Pedigree, Phenotype, Risk Factors, Sequence Analysis, DNA, Topography, Medical, Asian People genetics, Behcet Syndrome genetics, Commerce, DNA, Mitochondrial genetics, Evolution, Molecular, Genetic Markers, Silk economics, White People genetics
Abstract

Objectives: Behçet's disease is a multifactorial vasculitis that shows its highest prevalence in geographical areas historically involved in the Silk Road, suggesting that it might have originated somewhere along these ancient trade routes. This study aims to provide a first clue towards genetic evidence for this hypothesis by testing it via an anthropological evolutionary genetics approach., Methods: Behçet's disease variation at ancestry informative mitochondrial DNA control region and haplogroup diagnostic sites was characterised in 185 disease subjects of Italian descent and set into the Eurasian mitochondrial landscape by comparison with nearly 9,000 sequences representative of diversity observable in Italy and along the main Silk Road routes., Results: Dissection of the actual genetic ancestry of disease individuals by means of population structure, spatial autocorrelation and haplogroup analyses revealed their closer relationships with some Middle Eastern and Central Asian groups settled along the Silk Road than with healthy Italians., Conclusions: These findings support the hypothesis that the Behçet's disease genetic risk has migrated to western Eurasia in parallel with ancestry components typical of Silk Road-related groups. This provided new insights that are useful to improve the understanding of disease origins and diffusion, as well as to inform future association studies aimed at properly accounting for the actual genetic ancestry of the examined Behçet's disease samples in order to minimise the detection of spurious associations and to improve the identification of genetic variants with actual clinical relevance.

Published
2015

2. Tracing Behçet's disease origins along the Silk Road: An anthropological evolutionary genetics perspective

Author

MARCO SAZZINI, Garagnani, P., Sarno, S., Fanti, S., Lazzano, T., Yao, D. Y., Boattini, A., Pazzola, G., Maramotti, S., Boiardi, L., Franceschi, C., Salvarani, C., Luiselli, D., Sazzini, Marco, Garagnani, Paolo, Sarno, Stefania, De Fanti, Sara, Lazzano, Teresa, Yang Yao, Daniele, Boattini, Alessio, Pazzola, Giulia, Maramotti, Sally, Boiardi, Luigi, Franceschi, Claudio, Salvarani, Carlo, and Luiselli, Donata

Subjects
Genetic Markers, Asia, Behcet Syndrome, Commerce, Silk, Sequence Analysis, DNA, DNA, Mitochondrial, White People, Pedigree, Evolution, Molecular, Genetics, Population, Phenotype, Asian People, Haplotypes, Italy, Risk Factors, Cluster Analysis, Humans, Genetic Predisposition to Disease, Topography, Medical, Behçet’s disease, Silk Road, anthropological evolutionary genetics, mitochondrial DNA, gene flow
Abstract

OBJECTIVES: Behçet's disease is a multifactorial vasculitis that shows its highest prevalence in geographical areas historically involved in the Silk Road, suggesting that it might have originated somewhere along these ancient trade routes. This study aims to provide a first clue towards genetic evidence for this hypothesis by testing it via an anthropological evolutionary genetics approach. METHODS: Behçet's disease variation at ancestry informative mitochondrial DNA control region and haplogroup diagnostic sites was characterised in 185 disease subjects of Italian descent and set into the Eurasian mitochondrial landscape by comparison with nearly 9,000 sequences representative of diversity observable in Italy and along the main Silk Road routes. RESULTS: Dissection of the actual genetic ancestry of disease individuals by means of population structure, spatial autocorrelation and haplogroup analyses revealed their closer relationships with some Middle Eastern and Central Asian groups settled along the Silk Road than with healthy Italians. CONCLUSIONS: These findings support the hypothesis that the Behçet's disease genetic risk has migrated to western Eurasia in parallel with ancestry components typical of Silk Road-related groups. This provided new insights that are useful to improve the understanding of disease origins and diffusion, as well as to inform future association studies aimed at properly accounting for the actual genetic ancestry of the examined Behçet's disease samples in order to minimise the detection of spurious associations and to improve the identification of genetic variants with actual clinical relevance.

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