Search

Alkylation of benzofuranones (I) with alcohols in the presence of a chiral biscinchona catalyst affords the 3-alkylated product with good enantioselectivities up to 83% e.e. [ABSTRACT FROM AUTHOR]

Starting from 2-benzylidenebenzofuran-3-ones the synthesis of chiral dihydropyran-fused benzofurans is elaborated. [ABSTRACT FROM AUTHOR]

A highly enantioselective Mannich reaction of 3-substituted benzofuran-2(3 H )-ones and isatin N -Boc ketimines catalyzed by a chiral biscinchona alkaloid catalyst was developed, which proved to be an efficient way for the synthesis of chiral 3,3′-disubstituted benzofuran-2-one derivatives. The nucleophilic addition products were generally obtained in high yields (up to 99%) with very good diastereoselectivities (up to >95:5 dr) and enantioselectivities (up to 98% ee). [ABSTRACT FROM AUTHOR]

Chiral 3,3′-disubstituted benzofuranones are synthesized from the title addition in excellent yields with very good diastereoselectivities and enantioselectivities. [ABSTRACT FROM AUTHOR]