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Start Over Descriptor "Amodiaquine chemical synthesis" Topic benzofurans

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1 results on '"Amodiaquine chemical synthesis"'

1. [[1]Benzofuro[3,2-b]pyridin-4-yl-amines - synthesis and investigation of activity against malaria].

Author

Görlitzer K, Meyer H, Jomaa H, and Wiesner J

Subjects
Amodiaquine analogs & derivatives, Amodiaquine chemical synthesis, Amodiaquine pharmacology, Animals, Chemical Phenomena, Chemistry, Physical, Mannich Bases, Naphthyridines chemical synthesis, Naphthyridines pharmacology, Plasmodium falciparum drug effects, Amines chemical synthesis, Amines pharmacology, Antimalarials chemical synthesis, Antimalarials pharmacology, Benzofurans chemical synthesis, Benzofurans pharmacology
Abstract

The ethyl 4-chlorobenzofuro[3,2-b]pyridine-3-carboxylate (2) reacted with the hydrochlorides of the mono- and bis-phenol Mannich bases 3 to yield the amodiaquine and pyronaridine analogues 4. The chloroquine analogue 6 was formed by melting 2 with the novaldiamine base (5) in phenol. The most active compound 4c inhibited the growth of the malaria parasite Plasmodium falciparum with an IC50 of 500 nM.

Published
2004

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