1. Metal-Organic Framework Capillary Microreactor for Application in Click Chemistry.
- Author
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Truter, Lara A., Juan‐Alcañiz, Jana, Kapteijn, Freek, Nijhuis, Tjeerd A., Gascon, Jorge, and Schouten, Jaap C.
- Subjects
METAL-organic frameworks ,MICROREACTORS ,CLICK chemistry ,RING formation (Chemistry) ,BENZYL compounds - Abstract
A Cu/PMA-MIL-101(Cr) metal-organic-framework-coated microreactor has been applied in the 1,3-dipolar cycloaddition of benzyl azide and phenylactetylene (click chemistry). The Cu/PMA-MIL-101(Cr) catalyst was incorporated by using a washcoating method. The use of tetraethylorthosilicate (TEOS) and a copolymer pluronic F127 as binders resulted in a stable and uniform coating of 6 μm. The application of the Cu/PMA-MIL-101(Cr) capillary microreactor in the click-chemistry reaction resulted in a similar intrinsic activity as in the batch reactor, and a continuous production for more than 150 h time-on-stream could be achieved. The presence of water in the reagent feed led to reversible catalyst deactivation and was necessary to be removed to obtain a stable catalyst operation. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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