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A one-pot and three-component reaction is described for the preparation of 2,3-disubstituted isoindolin-1-ones. Heating a mixture of 2-formylbenzoic acid, a cyclic six-membered β-dicarbonyl compound, and a benzylamine under solvent-free conditions afforded the title compounds in good to excellent yields. The generality of the reaction was shown by the use of various β-dicarbonyl compounds including 1,3-cyclohexadione, dimedone, Meldrum’s acid, N , N -dimethylbarbituric acid, and some benzylamine derivatives. [ABSTRACT FROM AUTHOR]

Simply heating a mixture of β-dicarbonyl compounds, benzylamines, and acid (II) under solvent-free conditions gives isoindolines in good to excellent yields. [ABSTRACT FROM AUTHOR]