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Start Over Descriptor "Beta lactam antibiotics -- Structure" Topic beta lactamases -- physiological aspects
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1. Carbapenems and SHV-1 [beta]-lactamase form different acyl-enzyme populations in crystals and solution

Author

Kalp, Matthew and Carey, Paul R.

Subjects
Beta lactam antibiotics -- Structure, Beta lactam antibiotics -- Properties, Beta lactam antibiotics -- Research, Beta lactamases -- Structure, Beta lactamases -- Physiological aspects, Beta lactamases -- Research, Raman spectroscopy -- Usage, Biological sciences, Chemistry
Abstract

Raman microscopy is used for studying the reactions between single crystals of the SHV-1 [beta]-lactamase enzyme and the carbapenems, meropenem, imipenem and ertapenem. The studies have shown that mechanism-based inhibitors like carbapenems have behaved differently in the crystalline and solution phase of the SHV-1 [beta]-lactamase.

Published
2008

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