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2. The potential role of the osteopontin–osteocalcin–osteoprotegerin triad in the pathogenesis of prediabetes in humans

Author

Zuo Pengou, Jan M. Bruder, Devjit Tripathy, Franco Folli, Christopher P. Jenkinson, Deidre A. Winnier, Marcel Fourcaudot, Andrea Mari, Giuseppe Daniele, and Andrea Hansis-Diarte

Subjects
Blood Glucose, Male, Leptin, 0301 basic medicine, endocrine system diseases, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Impaired glucose tolerance, 0302 clinical medicine, Endocrinology, Insulin-Secreting Cells, Insulin, Euglycemic hyperinsulinemic clamp, Prediabetes, Glucose metabolism, C-Peptide, biology, Fasting, General Medicine, Middle Aged, Impaired fasting glucose, Diabetes and Metabolism, Osteocalcin, Female, Original Article, Adiponectin, hormones, hormone substitutes, and hormone antagonists, Human, Adult, medicine.medical_specialty, Impaired glucose regulation, Beta-cell function, Osteopontin, Osteoprotegerin, Type 2 diabetes mellitus, Whole body insulin sensitivity, Internal Medicine, 030209 endocrinology & metabolism, Prediabetic State, 03 medical and health sciences, Insulin resistance, Internal medicine, Glucose Intolerance, medicine, Humans, business.industry, nutritional and metabolic diseases, Glucose Tolerance Test, medicine.disease, 030104 developmental biology, Case-Control Studies, Glucose Clamp Technique, biology.protein, Blood sugar regulation, Insulin Resistance, business
Abstract

Aims To examine the relationship between hormones involved in bone remodeling and glucose metabolism alterations in prediabetes. Methods Individuals (n = 43) with NGT (BMI = 31.1 ± 1.1 kg/m2) and individuals (n = 79) with impaired glucose regulation (IGR) (BMI = 31.9 ± 1.2 kg/m2) including subjects with IFG, IGT, and IFG-IGT underwent OGTT and DXA. Osteopontin (OPN), osteocalcin (OCN), osteoprotegerin (OPG), and PTH levels were measured at fasting. Beta-cell function was calculated using C-peptide deconvolution. Dynamic indexes of insulin sensitivity were calculated from OGTT. A subgroup underwent to a euglycemic hyperinsulinemic clamp with 3-3H-glucose to estimate the endogenous glucose production (EGP) and insulin-mediated body glucose disposal (TGD/SSPI). Results OPN was higher in IGR compared to NGT (5.3 ± 0.5 vs. 3.3 ± 0.2 μg/mL; p = 0.008) and in isolated IGT compared to IFG and IFG-IGT (6.3 ± 0.5 vs. 4.5 ± 0.3 and 5.4 ± 0.5 μg/mL; p = 0.02). OCN was similar in IFG and NGT but lower in IGT and IFG-IGT compared to NGT (7.2 ± 0.3 and 5.4 ± 0.2 vs. 8.3 ± 0.3 ng/mL; p

Published
2017
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