This paper investigates the effect of double-frequency excitation on a fractional cerebral aneurysm model at the circle of Willis, where two kinds of external excitation are caused by the heart and arrhythmia respectively. Firstly, numerical analysis is performed on the proposed fractional model by using bifurcation diagrams and phase diagrams, and it is found that the periodic solution windows and chaotic solution windows switch more frequently than that resulted from single-frequency excitation, as a consequence of simultaneous resonances. Then, by using the method of multiple scales, the primary resonance response equation is obtained, and the effects of the system parameters on the amplitude of the fractional cerebral aneurysm model is analytically investigated. It is shown that double-frequency excitation changes the vibration patterns of the system under single-frequency excitation, and makes the primary resonance curve of the system deviate. Finally, the flexibility of using the amplitude-frequency equation to estimate the amplitude of the resonant solutions is verified numerically. [ABSTRACT FROM AUTHOR]