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The Precision Psychiatry is a new emergent topic in Psychiatry, and is “an approach for treatment and prevention that takes into account each person’s variability in genes, environment, and lifestyle”. It promises to be even more transformative than in other fields of medicine, because the psychiatry has not yet benefited from the advanced diagnostic and therapeutic technologies that now form an integral part of other clinical specialties. It may be an epistemological change in the field of psychiatry. This paper briefly highlights the story, the features, and the future of the Precision Psychiatry. Indeed, this approach is becoming a reality with the availability of massive data (derived from physiological recordings, brain imaging, ‘omics’ biomarkers, environmental exposures, self-reported experience).