1. Perioperative and Long-Term Outcome for Intrahepatic Cholangiocarcinoma: Impact of Major Versus Minor Hepatectomy.
- Author
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Zhang, Xu-Feng, Bagante, Fabio, Chakedis, Jeffery, Moris, Dimitrios, Beal, Eliza, Weiss, Matthew, Popescu, Irinel, Marques, Hugo, Aldrighetti, Luca, Maithel, Shishir, Pulitano, Carlo, Bauer, Todd, Shen, Feng, Poultsides, George, Soubrane, Oliver, Martel, Guillaume, Groot Koerkamp, B., Guglielmi, Alfredo, Itaru, Endo, and Pawlik, Timothy
- Subjects
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CHOLANGIOCARCINOMA , *INTRAHEPATIC bile ducts , *PERIOPERATIVE care , *HEPATECTOMY , *SURGICAL excision , *PROGRESSION-free survival , *THERAPEUTICS , *LONGITUDINAL method , *SURVIVAL analysis (Biometry) , *TREATMENT effectiveness ,BILE duct surgery ,BILE duct tumors - Abstract
Background: The objective of the current study was to investigate both short- and long-term outcomes of patients undergoing curative-intent resection for intrahepatic cholangiocarcinoma (ICC) stratified by extent of hepatic resection relative to overall final pathological margin status.Methods: One thousand twenty-three patients with ICC who underwent curative-intent resection were identified from a multi-institutional database. Demographic, clinicopathological, and operative data, as well as overall (OS) and recurrence-free survival (RFS) were compared among patients undergoing major and minor resection before and after propensity score matching.Results: Overall, 608 (59.4%) patients underwent major hepatectomy, while 415 (40.6%) had a minor resection. Major hepatectomy was more frequently performed among patients who had large, multiple, and bilobar tumors. Roughly half of patients (n = 294, 48.4%) developed a postoperative complication following major hepatectomy versus only one fourth of patients (n = 113, 27.2%) after minor resection (p < 0.001). In the propensity model, patients who underwent major hepatectomy had an equivalent OS and RFS versus patients who had a minor hepatectomy (median OS, 38 vs. 37 months, p = 0.556; and median RFS, 20 vs. 18 months, p = 0.635). Patients undergoing major resection had comparable OS and RFS with wide surgical margin (≥10 and 5-9 mm), but improved RFS when surgical margin was narrow (1-4 mm) versus minor resection in the propensity model. In the Cox regression model, tumor characteristics and surgical margin were independently associated with long-term outcome.Conclusions: Major hepatectomy for ICC was not associated with an overall survival benefit, yet was associated with increased perioperative morbidity. Margin width, rather than the extent of resection, affected long-term outcomes. Radical parenchymal-sparing resection should be advocated if a margin clearance of ≥5 mm can be achieved. [ABSTRACT FROM AUTHOR]- Published
- 2017
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